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Campo DC | Valor | Idioma |
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dc.contributor.author | Carneiro, Paula Fernandes | - |
dc.contributor.author | Pinto, Maria do Carmo Freire Ribeiro | - |
dc.contributor.author | Marra, Roberta Katlen Fusco | - |
dc.contributor.author | Silva, F. C. da | - |
dc.contributor.author | Resende, Jackson Antonio Lamounier Carmargos | - |
dc.contributor.author | Silva, Luiz Francisco Rocha e | - |
dc.contributor.author | Alves, Hilkem G. | - |
dc.contributor.author | Barbosa, Gleyce dos Santos | - |
dc.contributor.author | Vasconcellos, Marne Carvalho de | - |
dc.contributor.author | Lima, Emerson Silva | - |
dc.contributor.author | Pohlit, Adrian Martin | - |
dc.contributor.author | Ferreira, V?tor Francisco | - |
dc.date.accessioned | 2020-06-15T21:42:01Z | - |
dc.date.available | 2020-06-15T21:42:01Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://repositorio.inpa.gov.br/handle/1/17380 | - |
dc.description.abstract | A series of eighteen quinones and structurally-related oxiranes were synthesized and evaluated for in vitro inhibitory activity against the chloroquine-sensitive 3D7 clone of the human malaria parasite Plasmodium falciparum. 2-amino and 2-allyloxynaphthoquinones exhibited important antiplasmodial activity (median inhibitory concentrations (IC50) < 10 μM). Oxiranes 6 and 25, prepared respectively by reaction of α-lapachone and tetrachloro-p-quinone with diazomethane in a mixture of ether and ethanol, exhibited the highest antiplasmodial activity and low cytotoxicity against human fibroblasts (MCR-5 cell line). The active compounds could represent a good prototype for an antimalarial lead molecule. © 2015 Published by Elsevier Masson SAS. | en |
dc.language.iso | en | pt_BR |
dc.relation.ispartof | Volume 108, Pags. 134-140 | pt_BR |
dc.rights | Restrito | * |
dc.subject | 2 (allyloxy) 4h Spiro(naphthalene 1,2' Oxirane) 4 One | en |
dc.subject | 2 (phenylamino) 4h Spiro(naphthalene 1,2' Oxirane) 4 One | en |
dc.subject | 2 Amino 4h Spiro(naphthalene 1,2' Oxirane) 4 One | en |
dc.subject | 2,2 Dimethyl 2,3 Dihydro 4h Spiro[naphtho[2,3 B]furan 9,2' Oxiran] 4 One | en |
dc.subject | 2,3 Dichloro 4h Spiro(naphthalene 1,2' Oxirane) 4 One | en |
dc.subject | 4,5 Dichloro 3,6 Dimethoxyphthalonitrile | en |
dc.subject | 4,5,7,8 Tetrachloro 1 Oxaspiro[2.5]octa 4,7 Dien 6 One | en |
dc.subject | Antimalarial Agent | en |
dc.subject | Chloroquine | en |
dc.subject | Ethylene Oxide | en |
dc.subject | Ethylene Oxide Derivative | en |
dc.subject | Methyl 9 Phenanthryl Ether | en |
dc.subject | Naphthoquinone | en |
dc.subject | Quinone Derivative | en |
dc.subject | Unclassified Drug | en |
dc.subject | Antimalarial Agent | en |
dc.subject | Ethylene Oxide | en |
dc.subject | Quinone Derivative | en |
dc.subject | Antimalarial Activity | en |
dc.subject | Controlled Study | en |
dc.subject | Drug Screening | en |
dc.subject | Drug Structure | en |
dc.subject | Drug Synthesis | en |
dc.subject | Ic 50 | en |
dc.subject | In Vitro Study | en |
dc.subject | Inhibitory Concentration | en |
dc.subject | Nonhuman | en |
dc.subject | Plasmodium | en |
dc.subject | Plasmodium Falciparum | en |
dc.subject | X-ray Diffraction | en |
dc.subject | Cell Line | en |
dc.subject | Cell Survival | en |
dc.subject | Chemical Structure | en |
dc.subject | Chemistry | en |
dc.subject | Dose Response | en |
dc.subject | Drug Effects | en |
dc.subject | Drug Sensitivity | en |
dc.subject | Fibroblast | en |
dc.subject | Human | en |
dc.subject | Structure Activity Relation | en |
dc.subject | Synthesis | en |
dc.subject | Antimalarials | en |
dc.subject | Cell Line | en |
dc.subject | Cell Survival | en |
dc.subject | Dose-response Relationship, Drug | en |
dc.subject | Ethylene Oxide | en |
dc.subject | Fibroblasts | en |
dc.subject | Humans | en |
dc.subject | Molecular Structure | en |
dc.subject | Parasitic Sensitivity Tests | en |
dc.subject | Plasmodium Falciparum | en |
dc.subject | Quinones | en |
dc.subject | Structure-activity Relationship | en |
dc.title | Synthesis and antimalarial activity of quinones and structurally-related oxirane derivatives | en |
dc.type | Artigo | pt_BR |
dc.identifier.doi | 10.1016/j.ejmech.2015.11.020 | - |
dc.publisher.journal | European Journal of Medicinal Chemistry | pt_BR |
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