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dc.contributor.authorBoechat, Antonio Luiz-
dc.contributor.authorOgusku, Maurício Morishi-
dc.contributor.authorSadahiro, Aya-
dc.contributor.authorSantos, Maria Cristina dos-
dc.date.accessioned2020-06-15T21:49:46Z-
dc.date.available2020-06-15T21:49:46Z-
dc.date.issued2013-
dc.identifier.urihttps://repositorio.inpa.gov.br/handle/1/17872-
dc.description.abstractPrevious studies identified the functional polymorphism 1858C/T in the gene PTPN22 in association with several autoimmune diseases and with resistance to tuberculosis (TB). This study is the first to investigate the association between pulmonary TB and the PTPN22 1858C/T polymorphism in the Brazilian Amazon. We conducted a case-control study involving a group of 413 individuals, comprised of 208. TB carriers and 205 controls. No significant association between the PTPN22 1858T allele frequency in controls (2.4%) and TB carriers (2.7%, p= 0.982, odds ratio (OR). = 0.89, 95% confidence interval. = 0.37-2.13) was identified in the Brazilian Amazon population. An additional evaluation by meta-analysis, however, suggested a protective role of the T allele in relation to TB (pooled OR. = 0.44, p= 0.011). These results suggest that the PTPN22 1858T allele serves as a protective genetic factor for TB in those individuals who carry this minor allele. © 2013 Elsevier B.V.en
dc.language.isoenpt_BR
dc.relation.ispartofVolume 16, Pags. 310-313pt_BR
dc.rightsRestrito*
dc.subjectGenomic Dnaen
dc.subjectCase Control Studyen
dc.subjectControlled Studyen
dc.subjectDisease Predispositionen
dc.subjectDna Polymorphismen
dc.subjectEthnic Differenceen
dc.subjectGeneen
dc.subjectGene Frequencyen
dc.subjectGene Functionen
dc.subjectGene Linkage Disequilibriumen
dc.subjectGenetic Variabilityen
dc.subjectGenotypeen
dc.subjectGeographic Distributionen
dc.subjectHumanen
dc.subjectLung Tuberculosisen
dc.subjectMajor Clinical Studyen
dc.subjectMycobacterium Tuberculosisen
dc.subjectPopulation Researchen
dc.subjectPriority Journalen
dc.subjectPtpn22 Geneen
dc.subjectPolymorphism, Single Nucleotideen
dc.subjectAllelesen
dc.subjectCase-control Studiesen
dc.subjectDisease Resistanceen
dc.subjectGenetic Association Studiesen
dc.subjectHumansen
dc.subjectMutationen
dc.subjectOdds Ratioen
dc.subjectPolymorphism, Single Nucleotideen
dc.subjectProtein Tyrosine Phosphatase, Non-receptor Type 22en
dc.subjectTuberculosis, Pulmonaryen
dc.titleAssociation between the PTPN22 1858C/T gene polymorphism and tuberculosis resistanceen
dc.typeArtigopt_BR
dc.identifier.doi10.1016/j.meegid.2013.02.019-
dc.publisher.journalInfection, Genetics and Evolutionpt_BR
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