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Campo DC | Valor | Idioma |
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dc.contributor.author | Boechat, Antonio Luiz | - |
dc.contributor.author | Boechat, Narjara de Oliveira | - |
dc.contributor.author | Ogusku, Maurício Morishi | - |
dc.contributor.author | Alencar, Mariana Raposo | - |
dc.contributor.author | Abensur, Themis da Costa | - |
dc.contributor.author | Neto, José Cardoso | - |
dc.contributor.author | Amorim, Leilian de Souza | - |
dc.contributor.author | Oliveira, Lívia Moura de | - |
dc.contributor.author | Sadahiro, Aya | - |
dc.contributor.author | Santos, Maria Cristina dos | - |
dc.date.accessioned | 2020-06-15T21:50:04Z | - |
dc.date.available | 2020-06-15T21:50:04Z | - |
dc.date.issued | 2013 | - |
dc.identifier.uri | https://repositorio.inpa.gov.br/handle/1/17912 | - |
dc.description.abstract | Purpose: The aim of this study was to investigate the influence of the TNF -308 G/A polymorphism in the promoter region of the tumor necrosis factor- α gene on the susceptibility and severity of rheumatoid arthritis (RA) in individuals from the Brazilian Amazon. Methods: A total of 323 individuals-192 healthy controls without arthritis and 131 individuals suffering from arthritis-were genotyped for this polymorphism using a methodology based on PCR-RFLP. Results: The frequency of the A allele (TNF2) in rheumatoid arthritis sufferers was not significantly higher than in the controls (p= 0.926; OR = 0.97; confidence interval 0.54-1.76). However, using a logistic regression model, when the patients were stratified according to whether the manifestations were preponderantly articular or systemic, there was a strong association between the TNF2 allele and systemic arthritis (p= 0.001; OR = 5.89; confidence interval = 1.98-17.5) as well as the use of anti-TNF immunotherapy (p= 0.023; OR = 1.10; confidence interval = 1.00-1.14). The main factors that were found to influence the risk of extra-articular disease were age greater than or equal to 60. years (p= 0.008; OR = 4.06; confidence interval = 1.45-11.38), disease duration greater than 10. years (p= 0.031; OR = 3.10; confidence interval = 1.11-8.63) and positive rheumatoid factor (p= 0.035; OR = 2.07; confidence interval = 1.05-4.09). Conclusions: These results suggest that the TNF2 allele is associated with the more serious forms of the disease in individuals from the Brazilian Amazon but not with a risk for developing RA. © 2012 Elsevier Ltd. | en |
dc.language.iso | en | pt_BR |
dc.relation.ispartof | Volume 61, Número 2, Pags. 406-412 | pt_BR |
dc.rights | Restrito | * |
dc.subject | Disease Modifying Antirheumatic Drug | en |
dc.subject | Dna | en |
dc.subject | Rheumatoid Factor | en |
dc.subject | Tumor Necrosis Factor-alpha | en |
dc.subject | Tumor Necrosis Factor Alpha Inhibitor | en |
dc.subject | Adult | en |
dc.subject | Age | en |
dc.subject | Aged | en |
dc.subject | Clinical Feature | en |
dc.subject | Confidence Interval | en |
dc.subject | Controlled Study | en |
dc.subject | Das28 | en |
dc.subject | Disease Duration | en |
dc.subject | Disease Severity | en |
dc.subject | Dna Extraction | en |
dc.subject | Female | en |
dc.subject | Gene Frequency | en |
dc.subject | Polymorphism, Genetic | en |
dc.subject | Genetic Susceptibility | en |
dc.subject | Genotype | en |
dc.subject | Health Assessment Questionnaire | en |
dc.subject | Human | en |
dc.subject | Logistic Regression Analysis | en |
dc.subject | Major Clinical Study | en |
dc.subject | Male | en |
dc.subject | Polymerase Chain Reaction | en |
dc.subject | Priority Journal | en |
dc.subject | Promoter Region | en |
dc.subject | Polymorphism, Restriction Fragment Length | en |
dc.subject | Arthritis, Rheumatoid | en |
dc.subject | Risk Assessment | en |
dc.subject | Tnf Gene | en |
dc.subject | Adolescent | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Alleles | en |
dc.subject | Arthritis, Rheumatoid | en |
dc.subject | Case-control Studies | en |
dc.subject | Demography | en |
dc.subject | Female | en |
dc.subject | Genetic Predisposition To Disease | en |
dc.subject | Humans | en |
dc.subject | Joints | en |
dc.subject | Logistic Models | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Models, Genetic | en |
dc.subject | Polymorphism, Single Nucleotide | en |
dc.subject | Reproducibility Of Results | en |
dc.subject | Roc Curve | en |
dc.subject | Tumor Necrosis Factor-alpha | en |
dc.subject | Young Adult | en |
dc.title | The influence of a TNF gene polymorphism on the severity of rheumatoid arthritis in the Brazilian Amazon | en |
dc.type | Artigo | pt_BR |
dc.identifier.doi | 10.1016/j.cyto.2012.11.020 | - |
dc.publisher.journal | Cytokine | pt_BR |
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