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Use este identificador para citar ou linkar para este item: https://repositorio.inpa.gov.br/handle/1/17981
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dc.contributor.authorDavid, Susana Correia de Matos-
dc.contributor.authorSutre, Ana Filipa-
dc.contributor.authorSanca, A.-
dc.contributor.authorMané, A.-
dc.contributor.authorHenriques, V.-
dc.contributor.authorPortugal, Clara-
dc.contributor.authorSancho, Luísa-
dc.contributor.authorCardoso, Ângela-
dc.contributor.authorPaixão, Eleonora-
dc.contributor.authorDuarte, Elsa Leclerc-
dc.contributor.authorLeite, Clarice Queico Fujimura-
dc.contributor.authorSalem, Júlia Ignez-
dc.contributor.authorAntunes, Abílio-
dc.date.accessioned2020-06-15T21:50:39Z-
dc.date.available2020-06-15T21:50:39Z-
dc.date.issued2012-
dc.identifier.urihttps://repositorio.inpa.gov.br/handle/1/17981-
dc.description.abstractThe diagnosis of tuberculosis is seriously hampered in the absence of standard biosafety laboratory facilities for specimen concentration and Mycobacterium tuberculosis culture. Within a laboratory twinning arrangement, heat-fixed direct smear and sediment from 74 bleach-processed and 20 non-processed specimens from Cumura Hospital, Guinea-Bissau, were sent to Lisbon for molecular evaluation of rifampicin resistance. Sequence analysis of a 369 base-pair rpoB locus detected 3.2% (3/94) resistant specimens. To our knowledge, this represents the first report on the molecular analysis of M. tuberculosis from bleach-processed sputum, an alternative to current diagnostic practice in low-resource settings. © 2012 The Union.en
dc.language.isoenpt_BR
dc.relation.ispartofVolume 16, Número 11, Pags. 1535-1537pt_BR
dc.rightsRestrito*
dc.subjectDouble Stranded Dnaen
dc.subjectSodium Hypochloriteen
dc.subjectRifampicinen
dc.subjectAntibiotic Resistanceen
dc.subjectBacterial Geneen
dc.subjectControlled Studyen
dc.subjectDenaturing High Performance Liquid Chromatographyen
dc.subjectDna Extractionen
dc.subjectGene Frequencyen
dc.subjectGene Identificationen
dc.subjectGene Locusen
dc.subjectGene Mutationen
dc.subjectGuinea-bissauen
dc.subjectHumanen
dc.subjectLung Tuberculosisen
dc.subjectMajor Clinical Studyen
dc.subjectMolecular Diagnosisen
dc.subjectMutational Analysisen
dc.subjectPolymerase Chain Reactionen
dc.subjectPriority Journalen
dc.subjectRpob Geneen
dc.subjectSequence Analysisen
dc.subjectPolymorphism, Single Nucleotideen
dc.subjectSputum Smearen
dc.subjectAntitubercular Agentsen
dc.subjectBacterial Proteinsen
dc.subjectBase Sequenceen
dc.subjectCapacity Buildingen
dc.subjectClinical Laboratory Techniquesen
dc.subjectGuinea-bissauen
dc.subjectHumansen
dc.subjectLaboratoriesen
dc.subjectMicrobial Sensitivity Testsen
dc.subjectMycobacterium Tuberculosisen
dc.subjectPortugalen
dc.subjectRifampinen
dc.subjectSequence Analysisen
dc.subjectSodium Hypochloriteen
dc.subjectSpecimen Handlingen
dc.subjectSputumen
dc.subjectTuberculosisen
dc.titleTuberculosis diagnosis after bleach processing for early stage tuberculosis laboratory capacity buildingen
dc.typeArtigopt_BR
dc.identifier.doi10.5588/ijtld.11.0658-
dc.publisher.journalInternational Journal of Tuberculosis and Lung Diseasept_BR
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