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dc.contributor.authorFreire, Ana Karla Lima L.-
dc.contributor.authorBentes, Amaury dos Santos-
dc.contributor.authorLima Sampaio, Ivanete de-
dc.contributor.authorMatsuura, Ani Beatriz Jackisch-
dc.contributor.authorOgusku, Maurício Morishi-
dc.contributor.authorSalem, Júlia Ignez-
dc.contributor.authorWanke, Bodo-
dc.contributor.authorSouza, João Vicente Braga de-
dc.date.accessioned2020-06-15T21:51:12Z-
dc.date.available2020-06-15T21:51:12Z-
dc.date.issued2012-
dc.identifier.urihttps://repositorio.inpa.gov.br/handle/1/18047-
dc.description.abstractAs there are four major molecular types of Cryptococcus neoformans (VNI, VNII, VNIII and VNIV) and four molecular types of Cryptococcus gattii (VGI, VGII, VGIII and VGIV), it is important to identify the specific groups causing cryptococcosis in different geographical regions. Here, we investigated the molecular types of 57 cryptococcal isolates from patients in a tertiary care hospital in the state of Amazonas, Brazil, between 2006 and 2010. The isolates were characterised by PCR fingerprinting using the M13 minisatellite and confirmed by URA5-RFLP analysis, and the presence of specific genes from the mating type locus (MATα and MATa) of these species was analysed by PCR. Most of the patients were male (66.7%), between 16 and 30years of age (51.7%), and HIV-positive (75.0%). Most isolates were collected from cerebrospinal fluid samples (71.7%). Most of the C. neoformans isolates (n=40) were characterised as members of the VNI molecular group (n=39), a unique isolate was characterised as VNII whereas all isolates of C. gattii (n=17) were members of the VGII molecular group. With regard to mating types, 55 isolates were type 'α', and only two were type 'a'. This study revealed the prevalence of the VNI molecular group and provides the first reported observation of the VNII molecular group in the northern region of Brazil. © 2012 Blackwell Verlag GmbH.en
dc.language.isoenpt_BR
dc.relation.ispartofVolume 55, Número 3, Pags. e145-e150pt_BR
dc.rightsRestrito*
dc.subjectFungal Proteinen
dc.subjectUnclassified Drugen
dc.subjectUra5 Proteinen
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectCerebrospinal Fluiden
dc.subjectControlled Studyen
dc.subjectCryptococcosisen
dc.subjectCryptococcusen
dc.subjectCryptococcus Gattiien
dc.subjectCryptococcus Neoformansen
dc.subjectDna Fingerprintingen
dc.subjectFemaleen
dc.subjectFungal Geneen
dc.subjectFungus Isolationen
dc.subjectGene Expressionen
dc.subjectGene Locusen
dc.subjectHealthcare Facilityen
dc.subjectHumanen
dc.subjectHuman Immunodeficiency Virusen
dc.subjectHuman Immunodeficiency Virus Infectionen
dc.subjectMajor Clinical Studyen
dc.subjectMaleen
dc.subjectMolecular Geneticsen
dc.subjectPolymerase Chain Reactionen
dc.subjectPrevalenceen
dc.subjectPriority Journalen
dc.subjectPolymorphism, Restriction Fragment Lengthen
dc.subjectRisk Factoren
dc.subjectSpecies Diversityen
dc.subjectTertiary Health Careen
dc.subjectVariable Number Of Tandem Repeaten
dc.subjectVirus Isolationen
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAmbulatory Care Facilitiesen
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectCryptococcosisen
dc.subjectCryptococcusen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectMolecular Sequence Dataen
dc.subjectMycological Typing Techniquesen
dc.subjectPolymorphism, Restriction Fragment Lengthen
dc.subjectYoung Adulten
dc.subjectCryptococcus Gattiien
dc.subjectFilobasidiella Neoformansen
dc.titleMolecular characterisation of the causative agents of Cryptococcosis in patients of a tertiary healthcare facility in the state of Amazonas-Brazilen
dc.typeArtigopt_BR
dc.identifier.doi10.1111/j.1439-0507.2012.02173.x-
dc.publisher.journalMycosespt_BR
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