Título: | Synthesis and Antimalarial Activity of Dihydroperoxides and Tetraoxanes Conjugated with Bis(benzyl)acetone Derivatives |
Autor: | Franco, Lucas Lopardi Almeida, Mauro Vieira D. de Silva, Luiz Francisco Rocha e Vieira, Pedro Paulo Ribeiro Pohlit, Adrian Martin Valle, Marcelo Siqueira |
Palavras-chave: | 1,1' Peroxybis(4 Tert Butyl(hydroperoxy)cyclohexane 1,5 Bis(3,4,5 Trimethoxyphenyl)pentan 3 One 1,5 Bis(4 Methoxyphenyl)pentan 3 One 1,5 Bis(phenyl)penta 1,4 Dien 3 One 1,5 Bis(phenyl)pentan 3 One 3,3 Dihydroperoxy 1,5 (bisphenyl)pentane 3,3 Dihydroperoxy 1,5 Bis(4' Methoxyphenyl)pentane 3,3 Diphenethyl 1,2,4,5 Tetraoxaspiro[5.5]undecane 3,3,6,6 Tetraphenethyl 1,2,4,5 Tetraoxane 4 Tert Butyl 1,1 Dihydroperoxycyclohexane Tetrabenzene Acetone Antimalarial Agent Bis(arylmethyl)acetone Dihydroperoxide Hydroperoxide Derivative Tetraoxane Derivative Unclassified Drug Antimalarial Activity Controlled Study Drug Synthesis Human In Vitro Study Nonhuman Plasmodium Falciparum Priority Journal Acetone Antimalarials Humans Inhibitory Concentration 50 Malaria, Falciparum Peroxides Plasmodium Falciparum Structure-activity Relationship Tetraoxanes Plasmodium Falciparum |
Data do documento: | 2012 |
Revista: | Chemical Biology and Drug Design |
É parte de: | Volume 79, Número 5, Pags. 790-797 |
Abstract: | Dihydroperoxides and tetraoxanes derived from symmetrically substituted bis(arylmethyl)acetones were synthesized in modest to good yields using several methods. Three of these compounds exhibit an important in vitro antimalarial activity (1.0μm≤IC 50≤5.0μm) against blood forms of the human malaria parasite Plasmodium falciparum. © 2012 John Wiley & Sons A/S. |
DOI: | 10.1111/j.1747-0285.2012.01345.x |
Aparece nas coleções: | Artigos
|
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.