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Campo DC | Valor | Idioma |
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dc.contributor.author | Silva, Luiz Francisco Rocha e | - |
dc.contributor.author | Pinto, Ana Cristina da Silva | - |
dc.contributor.author | Pohlit, Adrian Martin | - |
dc.contributor.author | Quignard, Etienne Louis Jacques | - |
dc.contributor.author | Vieira, Pedro Paulo Ribeiro | - |
dc.contributor.author | Tadei, Wanderli Pedro | - |
dc.contributor.author | Chaves, Francisco Célio Maia | - |
dc.contributor.author | Samonek, Jean Francisco | - |
dc.contributor.author | Lima, Carlos Alberto Jatoba | - |
dc.contributor.author | Costa, Mônica Regina Farias | - |
dc.contributor.author | Alecrim, Maria das Graças Costa | - |
dc.contributor.author | Andrade Neto, Valter Ferreira de | - |
dc.date.accessioned | 2020-06-15T21:52:15Z | - |
dc.date.available | 2020-06-15T21:52:15Z | - |
dc.date.issued | 2011 | - |
dc.identifier.uri | https://repositorio.inpa.gov.br/handle/1/18169 | - |
dc.description.abstract | 4-Nerolidylcatechol (4-NC) isolated from Piper peltatum L. (Piperaceae) was evaluated for in vitro antiplasmodial activity against Plasmodium falciparum (cultures of both standard CQR (K1) and CQS (3D7) strains and two Amazonian field isolates) and for in vivo antimalarial activity using the Plasmodium berghei-murine model. 4-NC exhibits significant in vitro and moderate in vivo antiplasmodial activity. 4-NC administered orally and subcutaneously at doses of 200, 400 and 600 mg/kg/day suppressed the growth of P. berghei by up to 63% after four daily treatments (days 1-4). Also, 4-NC exhibited important in vitro antiplasmodial activity against both standard and field P. falciparum strains in which 50% inhibition of parasite growth (IC 50) was produced at concentrations of 0.05-2.11 μg/mL and depended upon the parasite strain. Interestingly, healthy (non-infected) mice that received 4-NC orally presented (denatured) blood plasma which exhibited significant in vitro activity against P. falciparum. This is evidence that mouse metabolism allows 4-NC or active metabolites to enter the blood. Further chemical and pharmacological studies are necessary to confirm the potential of 4-NC as a new antimalarial prototype. Copyright © 2011 John Wiley & Sons, Ltd. | en |
dc.language.iso | en | pt_BR |
dc.relation.ispartof | Volume 25, Número 8, Pags. 1181-1188 | pt_BR |
dc.rights | Restrito | * |
dc.subject | 4 Nerolidylcatechol | en |
dc.subject | Antimalarial Agent | en |
dc.subject | Catechol Derivative | en |
dc.subject | Chloroquine | en |
dc.subject | Unclassified Drug | en |
dc.subject | Animals Cell | en |
dc.subject | Animals Experiment | en |
dc.subject | Animals Model | en |
dc.subject | Antimalarial Activity | en |
dc.subject | Blood Sampling | en |
dc.subject | Concentration (parameters) | en |
dc.subject | Controlled Study | en |
dc.subject | Drug Determination | en |
dc.subject | Drug Dose Comparison | en |
dc.subject | Drug Inhibition | en |
dc.subject | Drug Metabolism | en |
dc.subject | Drug Structure | en |
dc.subject | Female | en |
dc.subject | Growth Inhibition | en |
dc.subject | Human | en |
dc.subject | Human Cell | en |
dc.subject | In Vitro Study | en |
dc.subject | In Vivo Study | en |
dc.subject | Malaria | en |
dc.subject | Microbial Growth | en |
dc.subject | Mouse | en |
dc.subject | Nonhuman | en |
dc.subject | Piper Peltatum | en |
dc.subject | Piperaceae | en |
dc.subject | Plasmodium Berghei | en |
dc.subject | Plasmodium Falciparum | en |
dc.subject | Treatment Response | en |
dc.subject | Animal | en |
dc.subject | Antimalarials | en |
dc.subject | Catechols | en |
dc.subject | Disease Models, Animals | en |
dc.subject | Female | en |
dc.subject | Malaria | en |
dc.subject | Malaria, Falciparum | en |
dc.subject | Mice | en |
dc.subject | Piper | en |
dc.subject | Plasmodium Berghei | en |
dc.subject | Plasmodium Falciparum | en |
dc.subject | Murinae | en |
dc.subject | Mus | en |
dc.subject | Piper Peltatum | en |
dc.subject | Piperaceae | en |
dc.subject | Plasmodium Berghei | en |
dc.subject | Plasmodium Falciparum | en |
dc.title | In vivo and in vitro antimalarial activity of 4-nerolidylcatechol | en |
dc.type | Artigo | pt_BR |
dc.identifier.doi | 10.1002/ptr.3424 | - |
dc.publisher.journal | Phytotherapy Research | pt_BR |
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