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Campo DC | Valor | Idioma |
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dc.contributor.author | Pinto, Ana Cristina da Silva | - |
dc.contributor.author | Silva, Luis Francisco Rocha | - |
dc.contributor.author | Coelho Cavalcanti, Bruno | - |
dc.contributor.author | Melo, Márcia R.S. | - |
dc.contributor.author | Chaves, Francisco Célio Maia | - |
dc.contributor.author | Costa-Lotufo, Leticia Veras | - |
dc.contributor.author | Moraes, Manœl Odorico de | - |
dc.contributor.author | Andrade Neto, Valter Ferreira de | - |
dc.contributor.author | Tadei, Wanderli Pedro | - |
dc.contributor.author | Pessoa, Cláudia do Ó. | - |
dc.contributor.author | Vieira, Pedro Paulo Ribeiro | - |
dc.contributor.author | Pohlit, Adrian Martin | - |
dc.date.accessioned | 2020-06-15T21:54:58Z | - |
dc.date.available | 2020-06-15T21:54:58Z | - |
dc.date.issued | 2009 | - |
dc.identifier.uri | https://repositorio.inpa.gov.br/handle/1/18433 | - |
dc.description.abstract | 4-Nerolidylcatechol (1) was isolated from cultivated Pothomorphe peltata root on a multigram scale using straight-forward solvent extraction-column chromatography. New semi-synthetic derivatives of 1 were prepared and tested in vitro against multidrug-resistant Plasmodium falciparum K1 strain. Mono-O-methyl, mono-O-benzyl, O,O-dibenzyl and O,O-dibenzoyl derivatives 2-8 exhibited IC50 in the 0.67-22.52 μM range. Mono-O-methyl ethers 6 and 7 inhibited the in vitro growth of human tumor cell lines HCT-8 (colon carcinoma), SF-295 (central nervous system), LH-60 (human myeloblastic leukemia) and MDA/MB-435 (melanoma). In general, derivatives 2-8 are more stable to light, air and pH at ambient temperatures than their labile, natural precursor 1. These derivatives provide leads for the development of a novel class of antimalarial drugs with enhanced chemical and pharmacological properties. © 2008 Elsevier Masson SAS. All rights reserved. | en |
dc.language.iso | en | pt_BR |
dc.relation.ispartof | Volume 44, Número 6, Pags. 2731-2735 | pt_BR |
dc.rights | Restrito | * |
dc.subject | 1 O Methyl 4 Nerolidylcatechol | en |
dc.subject | 2 O Methyl 4 Nerolidylcatechol | en |
dc.subject | 4 Nerolidylcatechol | en |
dc.subject | Antimalarial Agent | en |
dc.subject | Doxorubicin | en |
dc.subject | O,o Dibenzoyl 4 Nerolidylcatechol | en |
dc.subject | O,o Dibenzyl 4 Nerolidylcatechol | en |
dc.subject | Unclassified Drug | en |
dc.subject | Column Chromatography | en |
dc.subject | Controlled Study | en |
dc.subject | Cytotoxicity | en |
dc.subject | Drug Isolation | en |
dc.subject | Drug Stability | en |
dc.subject | Environmental Temperature | en |
dc.subject | Human | en |
dc.subject | Human Cell | en |
dc.subject | Ic 50 | en |
dc.subject | Malaria | en |
dc.subject | Medicinal Plant | en |
dc.subject | Ph Measurement | en |
dc.subject | Plasmodium Falciparum | en |
dc.subject | Pothomorphe Peltata | en |
dc.subject | Solvent Extraction | en |
dc.subject | Animal | en |
dc.subject | Antimalarials | en |
dc.subject | Antineoplastic Agents, Phytogenic | en |
dc.subject | Catechols | en |
dc.subject | Cell Line, Tumor | en |
dc.subject | Cell Proliferation | en |
dc.subject | Dose-response Relationship, Drug | en |
dc.subject | Drug Resistance | en |
dc.subject | Drug Screening Assays, Antitumor | en |
dc.subject | Hl-60 Cells | en |
dc.subject | Humans | en |
dc.subject | Molecular Structure | en |
dc.subject | Parasitic Sensitivity Tests | en |
dc.subject | Piperaceae | en |
dc.subject | Plant Extracts | en |
dc.subject | Plant Roots | en |
dc.subject | Plasmodium Falciparum | en |
dc.subject | Stereoisomerism | en |
dc.title | New antimalarial and cytotoxic 4-nerolidylcatechol derivatives | en |
dc.type | Artigo | pt_BR |
dc.identifier.doi | 10.1016/j.ejmech.2008.10.025 | - |
dc.publisher.journal | European Journal of Medicinal Chemistry | pt_BR |
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