Please use this identifier to cite or link to this item: https://repositorio.inpa.gov.br/handle/1/18449
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dc.contributor.authorMarcili, Arlei-
dc.contributor.authorValente, Vera da Costa-
dc.contributor.authorValente, Sebastiäo Aldo S.-
dc.contributor.authorJunqueira, Ângela Cristina Veríssimo-
dc.contributor.authorSilva, Flávia Maia da-
dc.contributor.authorPinto, Ana Yecê das Neves-
dc.contributor.authorNaiff, Roberto Daibes-
dc.contributor.authorCampaner, Marta-
dc.contributor.authorCoura, José Rodrigues-
dc.contributor.authorCamargo, Erney Plessmann-
dc.contributor.authorMiles, Michael Alexander-
dc.contributor.authorTeixeira, Marta Maria Geraldes-
dc.date.accessioned2020-06-15T21:55:11Z-
dc.date.available2020-06-15T21:55:11Z-
dc.date.issued2009-
dc.identifier.urihttps://repositorio.inpa.gov.br/handle/1/18449-
dc.description.abstractIn this study, we provide phylogenetic and biogeographic evidence that the Trypanosoma cruzi lineages T. cruzi I (TCI) and T. cruzi IIa (TCIIa) circulate amongst non-human primates in Brazilian Amazonia, and are transmitted by Rhodnius species in overlapping arboreal transmission cycles, sporadically infecting humans. TCI presented higher prevalence rates, and no lineages other than TCI and TCIIa were found in this study in wild monkeys and Rhodnius from the Amazonian region. We characterised TCI and TCIIa from wild primates (16 TCI and five TCIIa), Rhodnius spp. (13 TCI and nine TCIIa), and humans with Chagas disease associated with oral transmission (14 TCI and five TCIIa) in Brazilian Amazonia. To our knowledge, TCIIa had not been associated with wild monkeys until now. Polymorphisms of ssrDNA, cytochrome b gene sequences and randomly amplified polymorphic DNA (RAPD) patterns clearly separated TCIIa from TCIIb-e and TCI lineages, and disclosed small intra-lineage polymorphisms amongst isolates from Amazonia. These data are important in understanding the complexity of the transmission cycles, genetic structure, and evolutionary history of T. cruzi populations circulating in Amazonia, and they contribute to both the unravelling of human infection routes and the pathological peculiarities of Chagas disease in this region. © 2008 Australian Society for Parasitology Inc.en
dc.language.isoenpt_BR
dc.relation.ispartofVolume 39, Número 5, Pags. 615-623pt_BR
dc.rightsRestrito*
dc.subjectBiogeographyen
dc.subjectChagas Diseaseen
dc.subjectCytochromeen
dc.subjectDisease Transmissionen
dc.subjectDnaen
dc.subjectHominiden
dc.subjectInsecten
dc.subjectPathologyen
dc.subjectPhylogeneticsen
dc.subjectPhylogenyen
dc.subjectPrimateen
dc.subjectProtozoanen
dc.subjectAnimalen
dc.subjectAotidaeen
dc.subjectCebidaeen
dc.subjectChagas Diseaseen
dc.subjectCytochromes Ben
dc.subjectDna, Protozoanen
dc.subjectGenotypeen
dc.subjectHumansen
dc.subjectInsect Vectorsen
dc.subjectMonkey Diseasesen
dc.subjectPhylogenyen
dc.subjectPolymorphism, Geneticen
dc.subjectPrimatesen
dc.subjectRandom Amplified Polymorphic Dna Techniqueen
dc.subjectRhodniusen
dc.subjectSaguinusen
dc.subjectSpecies Specificityen
dc.subjectTrypanosoma Cruzien
dc.subjectAmazoniaen
dc.subjectSouth Americaen
dc.subjectCytochrome Ben
dc.subjectProtozoal Dnaen
dc.subjectAnimalsen
dc.subjectAotidaeen
dc.subjectCebidaeen
dc.subjectChagas Diseaseen
dc.subjectClassificationen
dc.subjectDisease Carrieren
dc.subjectPolymorphism, Geneticen
dc.subjectGeneticsen
dc.subjectGenotypeen
dc.subjectHumanen
dc.subjectIsolation And Purificationen
dc.subjectMonkey Diseasesen
dc.subjectParasitologyen
dc.subjectPhylogenyen
dc.subjectPrimateen
dc.subjectProceduresen
dc.subjectRandom Amplified Polymorphic Dnaen
dc.subjectRhodniusen
dc.subjectSaguinusen
dc.subjectSpecies Differenceen
dc.subjectTransmissionen
dc.subjectTrypanosoma Cruzien
dc.subjectVeterinaryen
dc.subjectAnimalen
dc.subjectAotidaeen
dc.subjectCebidaeen
dc.subjectChagas Diseaseen
dc.subjectCytochromes Ben
dc.subjectDna, Protozoanen
dc.subjectGenotypeen
dc.subjectHumansen
dc.subjectInsect Vectorsen
dc.subjectMonkey Diseasesen
dc.subjectPhylogenyen
dc.subjectPolymorphism, Geneticen
dc.subjectPrimatesen
dc.subjectRandom Amplified Polymorphic Dna Techniqueen
dc.subjectRhodniusen
dc.subjectSaguinusen
dc.subjectSpecies Specificityen
dc.subjectTrypanosoma Cruzien
dc.titleTrypanosoma cruzi in Brazilian Amazonia: Lineages TCI and TCIIa in wild primates, Rhodnius spp. and in humans with Chagas disease associated with oral transmissionen
dc.typeArtigopt_BR
dc.identifier.doi10.1016/j.ijpara.2008.09.015-
dc.publisher.journalInternational Journal for Parasitologypt_BR
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