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Campo DC | Valor | Idioma |
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dc.contributor.author | Napimoga, Marcelo Henrique | - |
dc.contributor.author | Manfredo Vieira, Silvio | - |
dc.contributor.author | Dal-Secco, Daniela | - |
dc.contributor.author | Freitas, Andressa de | - |
dc.contributor.author | Souto, Fabrício Oliveira | - |
dc.contributor.author | Mestriner, Fabíola Leslie Antunes C. | - |
dc.contributor.author | Alves-Filho, J. C. | - |
dc.contributor.author | Grespan, Renata | - |
dc.contributor.author | Kawai, Toshihisa | - |
dc.contributor.author | Ferreira, Seérgio Henrique | - |
dc.contributor.author | Cunha, Fernando Queiroz | - |
dc.date.accessioned | 2020-06-15T22:02:15Z | - |
dc.date.available | 2020-06-15T22:02:15Z | - |
dc.date.issued | 2008 | - |
dc.identifier.uri | https://repositorio.inpa.gov.br/handle/1/18606 | - |
dc.description.abstract | Ligands for peroxisome proliferator-activated receptor γ (PPAR-γ), such as 15-deoxy-Δ12,14-prostaglandin J 2 (15d-PGJ2) have been implicated as a new class of anti-inflammatory compounds with possible clinical applications. Based on this concept, this investigation was designed to determine the effect of 15d-PGJ 2-mediated activation of PPAR-γ ligand on neutrophil migration after an inflammatory stimulus and clarify the underlying molecular mechanisms using a mouse model of peritonitis. Our results demonstrated that 15d-PGJ 2 administration decreases leukocyte rolling and adhesion to the inflammated mesenteric tissues by a mechanism dependent on NO. Specifically, pharmacological inhibitors of NO synthase remarkably abrogated the 15d-PGJ 2-mediated suppression of neutrophil migration to the inflammatory site. Moreover, inducible NOS-/- mice were not susceptible to 15d-PGJ2-mediated suppression of neutrophil migration to the inflammatory sites when compared with their wild type. In addition, 15d-PGJ 2-mediated suppression of neutrophil migration appeared to be independent of the production of cytokines and chemokines, since their production were not significantly affected in the carrageenan-injected peritoneal cavities. Finally, upregulation of carrageenan-triggered ICAM-1 expression in the mesenteric microcirculation vessels was abrogated by pretreatment of wild-type mice with 15d-PGJ2, whereas 15d-PGJ 2 inhibited F-actin rearrangement process in neutrophils. Taken together these findings demonstrated that 15d-PGJ2 suppresses inflammation-initiated neutrophil migration in a mechanism dependent on NO production in mesenteric tissues. Copyright © 2007 by The American Association of Immunologists, Inc. | en |
dc.language.iso | en | pt_BR |
dc.relation.ispartof | Volume 180, Número 1, Pags. 609-617 | pt_BR |
dc.rights | Restrito | * |
dc.subject | 15 Deoxy Delta12,14 Prostaglandin J2 | en |
dc.subject | Carrageenan | en |
dc.subject | Chemokine | en |
dc.subject | Cytokine | en |
dc.subject | F Actin | en |
dc.subject | Inducible Nitric Oxide Synthase | en |
dc.subject | Intercellular Adhesion Molecule-1 | en |
dc.subject | Ligand | en |
dc.subject | Nitric Oxide | en |
dc.subject | Nitric Oxide Synthase Inhibitor | en |
dc.subject | Peroxisome Proliferator Activated Receptor Gamma | en |
dc.subject | 15 Deoxy Delta12,14 Prostaglandin J2 | en |
dc.subject | 15 Deoxy Delta12,14 Prostaglandin J2 | en |
dc.subject | Actin | en |
dc.subject | Carrageenan | en |
dc.subject | Drug Derivative | en |
dc.subject | Inducible Nitric Oxide Synthase | en |
dc.subject | Intercellular Adhesion Molecule-1 | en |
dc.subject | Nitric Oxide | en |
dc.subject | Peroxisome Proliferator Activated Receptor Gamma | en |
dc.subject | Prostaglandin D2 | en |
dc.subject | Unclassified Drug | en |
dc.subject | Animals Cell | en |
dc.subject | Animals Experiment | en |
dc.subject | Animals Model | en |
dc.subject | Animals Tissue | en |
dc.subject | Controlled Study | en |
dc.subject | Cytokine Production | en |
dc.subject | Disease Model | en |
dc.subject | Genetic Susceptibility | en |
dc.subject | Immunomodulation | en |
dc.subject | Immunostimulation | en |
dc.subject | Inflammation | en |
dc.subject | Leukocyte Adherence | en |
dc.subject | Leukocyte Migration Inhibition | en |
dc.subject | Leukocyte Rolling | en |
dc.subject | Male | en |
dc.subject | Mesentery | en |
dc.subject | Mesentery Blood Flow | en |
dc.subject | Mesentery Blood Vessel | en |
dc.subject | Mouse | en |
dc.subject | Neutrophil | en |
dc.subject | Nonhuman | en |
dc.subject | Peritoneal Cavity | en |
dc.subject | Peritonitis | en |
dc.subject | Priority Journal | en |
dc.subject | Protein Expression | en |
dc.subject | Up-regulation | en |
dc.subject | Wild Type | en |
dc.subject | Animals | en |
dc.subject | Capillary | en |
dc.subject | Cell Adhesion | en |
dc.subject | Drug Antagonism | en |
dc.subject | Drug Effect | en |
dc.subject | Genetics | en |
dc.subject | Immunology | en |
dc.subject | Leukocyte Rolling | en |
dc.subject | Metabolism | en |
dc.subject | Microcirculation | en |
dc.subject | Mouse Mutant | en |
dc.subject | Vascularization | en |
dc.subject | Actins | en |
dc.subject | Animal | en |
dc.subject | Capillaries | en |
dc.subject | Carrageenan | en |
dc.subject | Cell Adhesion | en |
dc.subject | Intercellular Adhesion Molecule-1 | en |
dc.subject | Leukocyte Rolling | en |
dc.subject | Ligands | en |
dc.subject | Male | en |
dc.subject | Mesentery | en |
dc.subject | Mice | en |
dc.subject | Mice, Knockout | en |
dc.subject | Microcirculation | en |
dc.subject | Neutrophils | en |
dc.subject | Nitric Oxide | en |
dc.subject | Nitric Oxide Synthase Type Iii | en |
dc.subject | Ppar Gamma | en |
dc.subject | Prostaglandin D2 | en |
dc.title | Peroxisome proliferator-activated receptor-γ ligand, 15-deoxy-Δ12,14-prostaglandin J2, reduces neutrophil migration via a nitric oxide pathway | en |
dc.type | Artigo | pt_BR |
dc.publisher.journal | Journal of Immunology | pt_BR |
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