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Title: Median lethal concentrations of amazonian plant extracts in the brine shrimp assay
Authors: Quignard, Etienne Louis Jacques
Nunomura, Sergio Massayoshi
Pohlit, Adrian Martin
Alecrim, Alexandre Mascarenhas
Pinto, Ana Cristina da Silva
Portela, Cíntia Nicácio
Oliveira, Laura Cristina Pereira de
Don, Luciana de Castro
Silva, Luiz Francisco Rocha e
Henrique, Marycleuma Campos
Santos, Mirian dos
Pinto, Patrícia de Souza
Silva, Suniá Gomes
Keywords: Antineoplastic Agent
Aspidosperma Marcgravianum Extract
Aspidosperma Nitidum Extract
Aspidosperma Vargasii Extract
Cassia Fastuosa Extract
Croton Cajucara Extract
Geissospermum Argentum Extract
Micrandropsis Scleroxylon Extract
Minquartia Guianensis Extract
New Drug
Piper Aduncum Extract
Piper Baccans Extract
Piper Capitarianum Extract
Piper Crytopodon Extract
Piper Dilatatum Extract
Piper Erectipilum Extract
Piper Hostmannianum Extract
Piper Tuberculatum Extract
Plant Extract
Pothomorphe Peltata Extract
Protium Aracouchini Extract
Tabebuia Incana Extract
Tapura Amazonica Extract
Unclassified Drug
Brine Shrimp Assay
Drug Determination
Drug Screening
Toxicity Testing
Medicine, Traditional
Artemia Franciscana
Decapoda (crustacea)
Lepianthes Peltata
Piper Aduncum
Piper Dilatatum
Piper Swartzianum
Pontoporia Blainvillei
Protium Aracouchini
Tapura Amazonica
Issue Date: 2004
metadata.dc.publisher.journal: Pharmaceutical Biology
metadata.dc.relation.ispartof: Volume 42, Número 3, Pags. 253-257
Abstract: In the current study, median lethal concentrations (LC50) were obtained in the brine shrimp assay (BSA) for 31 methanol and water plant extracts representing 21 Amazonian plant species, most of which are used in traditional medicine. The following species presented extracts with LC 50 values less than 50 μg/ml: Croton cajucara Benth., Micrandropsis scleroxylon W.A. Rodrigues, Piper aduncum L., P. hostmannianum (Miq.) C. DC., P. tuberculatum Jacq., Protium aracouchini (Aubl.) Marchand, and Tapura amazonica Poepp. The methanol extract of T. amazonica Poepp., a species known to be toxic according to ethnobotanic reports, was the most active (LC50 1.2 μg/ml). The data presented are considered useful as general toxicity parameters, and their relevance in the context of discovery of new antitumor agents and potential sources of (new) bioactive compounds in the Amazonian flora is discussed.
metadata.dc.identifier.doi: 10.1080/13880200490514186
Appears in Collections:Artigos

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