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|Title:||Paracoccidioides brasiliensis isolated from armadillos is virulent to Syrian hamsters|
|Authors:||Pera?oli, Maria Terezinha Serrão|
Sugizaki, Maria Fátima
Mendes, Rinaldo Pôncio
Naiff, Roberto Daibes
Montenegro, Mário Rubens Guimarães
South American Blastomycosis
|metadata.dc.relation.ispartof:||Volume 148, Número 3, Pags. 123-130|
|Abstract:||Isolates of Paracoccidioides brasiliensis may vary in virulence according to time of in vitro subcultivation. The present study compared the morphology and pathogenicity to hamsters of two P. brasiliensis isolates: one obtained from human lesions and maintained in the laboratory for several years (Pb-18) and the other isolate recovered from hamsters inoculated with organ homogenates from armadillos (Pb-T). The microscopic morphology of Pb-18 and Pb-T showed yeast cells with similar diameter. However, Pb-T produced a significantly higher number of buds per mother cell than Pb-18. Besides, the mycelial form of Pb-T developed abundant sporulation during 8 weeks of culture which was absent in the Pb-18 isolate. Virulence studies demonstrated that mortality rates, antibody levels, fungal load and extent of lesions in the organs were significantly higher in animals infected with Pb-T. The results demonstrated that Pb-T recently isolated from an animal was more virulent than Pb-18. These differences between the two P. brasillensis isolates may be indicators of virulence attenuation in this fungal species.|
|Appears in Collections:||Artigos|
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