Please use this identifier to cite or link to this item: https://repositorio.inpa.gov.br/handle/1/19289
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dc.contributor.authorSousa, Alexandra O.-
dc.contributor.authorHenry, Scarlett-
dc.contributor.authorMarója, Fatima M.-
dc.contributor.authorLee, H. K.-
dc.contributor.authorBrum, Laura-
dc.contributor.authorSingh, Mahavir V.-
dc.contributor.authorLagrange, P. H.-
dc.contributor.authorAucouturier, Pièrre-
dc.date.accessioned2020-06-15T22:07:04Z-
dc.date.available2020-06-15T22:07:04Z-
dc.date.issued1998-
dc.identifier.urihttps://repositorio.inpa.gov.br/handle/1/19289-
dc.description.abstractImmunoenzymatic assays were developed for the measurement of antibodies against mycobacterial lipoarabinomannan (LAM), a cell-free proteic extract (CFX) of Mycobacterium leprae, and the 38-kD protein antigen of M. tuberculosis. Sera from 108 leprosy patients, belonging to all clinical- immunological forms of the spectrum, and 81 patients with localized or disseminated tuberculosis (TB) were tested for antibodies of the four IgG subclasses. Standard calibration curves were used to allow comparisons between results of different isotypes and specificities. Mean concentrations of total IgG antibodies were higher in the overall leprosy population than in TB patients. In leprosy, levels of anti-CFX increased from tuberculoid toward lepromatous forms, with a clear switch from IgG1 to IgG2 subclass predominance. A similar IgG1 to IgG2 conversion was observed in anti-LAM antibodies, although total levels of anti-LAM were similar in patients with tuberculoid and lepromatous forms. In TB, antibodies against polysaccharide and protein antigens were both predominantly of IgG1 subclass, whatever the patient's clinical status, although lower in disseminated forms, probably due to concomitant HIV infection. A hypergammaglobulinaemia was also found in most leprosy and TB patients. In TB this was due to increased IgG1 and IgG3, especially in HIV co-infected patients. Based on the current knowledge of the influence of T cell-secreted cytokines on human immunoglobulin isotype expression, these results do not fit with a putative role of Th1 (such as found in TB and tuberculoid leprosy (TT)) and Th2 (such as found in leprosy lepromatous (LL) leprosy) environment in the isotypy of antibody responses in mycobacterial infections. Nor do variations of isotypy according to pathological conditions seem to be related to the biochemical nature of antigens, since antibodies to LAM and protein antigens had comparable evolutions of their subclass distribution. Other factors are to be investigated in order to understand better the significance and possible roles of antibodies in mycobacterial diseases.en
dc.language.isoenpt_BR
dc.relation.ispartofVolume 111, Número 1, Pags. 48-55pt_BR
dc.rightsRestrito*
dc.subjectBacterial Polysaccharideen
dc.subjectBacterial Proteinen
dc.subjectImmunoglobulin Gen
dc.subjectImmunoglobulin G1en
dc.subjectImmunoglobulin G2en
dc.subjectImmunoglobulin G3en
dc.subjectImmunoglobulin G4en
dc.subjectMycobacterium Antigenen
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAntibody Detectionen
dc.subjectAntibody Responseen
dc.subjectAntibody Titeren
dc.subjectChilden
dc.subjectFemaleen
dc.subjectHumanen
dc.subjectHuman Immunodeficiency Virus Infectionen
dc.subjectHypergammaglobulinemiaen
dc.subjectImmunoglobulin Blood Levelen
dc.subjectLepromatous Leprosyen
dc.subjectLung Tuberculosisen
dc.subjectMajor Clinical Studyen
dc.subjectMaleen
dc.subjectMiliary Tuberculosisen
dc.subjectMycobacterium Lepraeen
dc.subjectMycobacterium Tuberculosisen
dc.subjectPriority Journalen
dc.subjectSuperinfectionen
dc.subjectTuberculoid Leprosyen
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 And Overen
dc.subjectAntibodies, Bacterialen
dc.subjectAntigens, Bacterialen
dc.subjectBacterial Proteinsen
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectImmunoglobulin Gen
dc.subjectLeprosyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectMycobacterium Lepraeen
dc.subjectMycobacterium Tuberculosisen
dc.subjectPolysaccharides, Bacterialen
dc.subjectTuberculosisen
dc.titleIgG subclass distribution of antibody responses to protein and polysaccharide mycobacterial antigens in leprosy and tuberculosis patientsen
dc.typeArtigopt_BR
dc.identifier.doi10.1046/j.1365-2249.1998.00452.x-
dc.publisher.journalClinical and Experimental Immunologypt_BR
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