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dc.contributor.authorCabral, Jose A.-
dc.contributor.authorMcChesney, James Dewey-
dc.contributor.authorMilhous, Wilbur K.-
dc.date.accessioned2020-06-15T22:09:20Z-
dc.date.available2020-06-15T22:09:20Z-
dc.date.issued1993-
dc.identifier.urihttps://repositorio.inpa.gov.br/handle/1/19509-
dc.description.abstractTwo antimalarial quassinoids, gutolactone [1] and simalikalactone D [2], have been characterized by bioactivity-directed fractionation from the bark of Simaba guianensis collected near Manaus, Brazil. Compound 2 was previously isolated from Simaba multiflora and Quassia africana and shown to be an active antimalarial in vitro. This is the first occurrence of 1. The structure of the novel quassinoid was established by spectral methods including 2D nmr spectroscopy. © 1993, American Chemical Society. All rights reserved.en
dc.language.isoenpt_BR
dc.relation.ispartofVolume 56, Número 11, Pags. 1954-1961pt_BR
dc.rightsRestrito*
dc.subjectQuassinoid Derivativeen
dc.subjectAntimalarial Activityen
dc.subjectDrug Isolationen
dc.subjectDrug Structureen
dc.subjectNonhumanen
dc.subjectPlasmodium Falciparumen
dc.subjectTreeen
dc.subjectAnimalsen
dc.subjectAntimalarialsen
dc.subjectBicyclo Compoundsen
dc.subjectChromatography, Thin Layeren
dc.subjectGlaucarubinen
dc.subjectMagnetic Resonance Spectroscopyen
dc.subjectPlant Extractsen
dc.subjectPlants, Medicinalen
dc.subjectPlasmodium Falciparumen
dc.subjectSpectrophotometry, Ultravioleten
dc.subjectSupport, Non-u.S. Gov'ten
dc.subjectPlasmodium Falciparumen
dc.subjectQuassiaen
dc.subjectQuassia Africanaen
dc.subjectSimabaen
dc.titleA new antimalarial quassinoid from Simaba guianensisen
dc.typeArtigopt_BR
dc.identifier.doi10.1021/np50101a014-
dc.publisher.journalJournal of Natural Productspt_BR
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