Factors influencing susceptibility testing of antifungal drugs: a critical review of document M27-A4 from the Clinical and Laboratory Standards Institute (CLSI)

Sousa, Edinaira Sulany Oliveira de; Cortêz, Ana Cláudia Alves; Melhem, Márcia de Souza Carvalho; Frickmann, Hagen; Souza, João Vicente Braga de

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Campo DC	Valor	Idioma
dc.contributor.author	Sousa, Edinaira Sulany Oliveira de	-
dc.contributor.author	Cortêz, Ana Cláudia Alves	-
dc.contributor.author	Melhem, Márcia de Souza Carvalho	-
dc.contributor.author	Frickmann, Hagen	-
dc.contributor.author	Souza, João Vicente Braga de	-
dc.date.accessioned	2020-08-14T20:50:44Z	-
dc.date.available	2020-08-14T20:50:44Z	-
dc.date.issued	2020	-
dc.identifier.uri	https://repositorio.inpa.gov.br/handle/1/36325	-
dc.language.iso	en	pt_BR
dc.title	Factors influencing susceptibility testing of antifungal drugs: a critical review of document M27-A4 from the Clinical and Laboratory Standards Institute (CLSI)	pt_BR
dc.type	Artigo	pt_BR
dc.identifier.doi	10.1007/s42770-020-00354-6	-
dc.publisher.journal	Brazilian Journal of Microbiology	pt_BR
dc.description.resumo	Due to the increasing numbers of fungal infections and the emergence of drug-resistant fungi, optimization and standardization of diagnostic methods for the measurement of antifungal susceptibility are ongoing. The M27-A4 document by the US Clinical and Laboratory Standards Institute (CLSI) is presently used for the interpretation of minimum inhibitory concentrations of major opportunistic yeast species as measured by broth microdilution testing in many countries. Although microdilution is considered a benchmark for reproducible and accurate results, increased testing capacity, and limited human bias, the method is often inaccessible to routine clinical laboratories and researchers, especially in low-income countries. Furthermore, several studies suggest that there are still a considerable number of factors that make the estimation of in vitro activity of antifungal agents challenging. This review article summarizes the limitations of the M27-A4 standard which, despite the advances and improvements obtained by the standardization of antimicrobial resistance testing methods by CLSI, still persist. © 2020, Sociedade Brasileira de Microbiologia.	pt_BR
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