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Campo DC | Valor | Idioma |
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dc.contributor.author | Lenzi, Raquely M. | - |
dc.contributor.author | Campestrini, Luciano Henrique | - |
dc.contributor.author | Semprebon, Simone Cristine | - |
dc.contributor.author | Paschoal, J. A.R. | - |
dc.contributor.author | Silva, Monique A.G. | - |
dc.contributor.author | Zawadzki-Baggio, Selma Faria | - |
dc.contributor.author | Mantovani, Mário Sérgio | - |
dc.contributor.author | Petkowicz, Carmen L.O. | - |
dc.contributor.author | Maurer, Juliana Bello Baron | - |
dc.date.accessioned | 2021-08-25T15:13:21Z | - |
dc.date.available | 2021-08-25T15:13:21Z | - |
dc.date.issued | 2021 | - |
dc.identifier.uri | https://repositorio.inpa.gov.br/handle/1/37989 | - |
dc.description.abstract | The consumption of glucosinolate (GL)-rich foods, including Brassica vegetables, such as mustard, broccoli, and maca, is associated with decreased risk of developing cancer. The GL content in maca, which is recognized as a “superfood”, is approximately 100-times higher than that in other brassicas. Although maca is a potential dietary source of GLs, limited studies have examined the bioactivity of maca GLs using the combination of chemical characterization and bioassays. In this study, the fractions (Lm-II and Lm-III) rich in intact GLs (glucotropaeolin and glucolimnanthin) were isolated and characterized from maca ethanolic extracts using chromatography and mass spectrometry. Additionally, the growth-inhibitory effects of Lm-II and Lm-II fractions against hepatocellular carcinoma (HepG2/C3A) and colon adenocarcinoma (HT29) cell lines were examined in the absence or presence of myrosinase (MYR). Fractions lacking low molecular weight sugars dose-dependently exerted cytotoxic effects in the presence of MYR. The half-maximal inhibitory concentration values of Lm-II and Lm-III against HepG2/C3A were 118.8 and 69.9 µg/mL, respectively, while those against HT29 were 102.6 and 71.5 µg/mL, respectively. These results suggest that the anticancer properties of maca can be attributed to GLs and corroborate the categorization of maca as a “superfood.” Supplemental data for this article is available online at https://doi.org/10.1080/01635581.2021.1952444. © 2021 Taylor & Francis Group, LLC. | en |
dc.title | Glucosinolate-Enriched Fractions from Maca (Lepidium meyenii) Exert Myrosinase-Dependent Cytotoxic Effects against HepG2/C3A and HT29 Tumor Cell Lines | pt_BR |
dc.type | Artigo | pt_BR |
dc.identifier.doi | 10.1080/01635581.2021.1952444 | - |
dc.publisher.journal | Nutrition and Cancer | en |
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