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Campo DC | Valor | Idioma |
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dc.contributor.author | Pontes, Gemilson Soares | - |
dc.contributor.author | Naveca, Felipe Gomes | - |
dc.contributor.author | Santos, João Hugo Abdalla | - |
dc.contributor.author | Nascimento, Valdinete Alves do | - |
dc.contributor.author | Oliveira, Leonardo Calheiros de | - |
dc.contributor.author | Silva, Jean de Melo | - |
dc.contributor.author | Melo, Sabrina Araújo de | - |
dc.contributor.author | Alves, Carlos Eduardo de Castro | - |
dc.date.accessioned | 2022-06-28T17:14:48Z | - |
dc.date.available | 2022-06-28T17:14:48Z | - |
dc.date.issued | 2022 | - |
dc.identifier.uri | https://repositorio.inpa.gov.br/handle/1/38666 | - |
dc.description.abstract | The systemic inflammatory response elicited by acute Zika virus (ZIKV) infection during pregnancy plays a key role in the clinical outcomes in mothers and congenitally infected offspring. The present study aimed to evaluate the serum levels of GDF-3 and inflammasome-related markers in pregnant women during acute ZIKV infection. Serum samples from pregnant (n = 18) and non-pregnant (n = 22) women with acute ZIKV infection were assessed for NLRP3, IL-1β, IL-18, and GDF3 markers through an enzyme-linked immunosorbent assay. ZIKV-negative pregnant (n = 18) and non-pregnant women (n = 15) were used as control groups. All serum markers were highly elevated in the ZIKV-infected groups in comparison with control groups (p < 0.0001). Among the ZIKV-infected groups, the serum markers were significantly augmented in the pregnant women in comparison with non-pregnant women (NLRP3 p < 0.001; IL-1β, IL-18, and GDF3 p < 0.0001). The IL-18 marker was found at significantly higher levels (p < 0.05) in the third trimester of pregnancy. Bivariate and multivariate analyses showed a strong positive correlation between GDF3 and NLRP3 markers among ZIKV-infected pregnant women (r = 0.91, p < 0.0001). The findings indicated that acute ZIKV infection during pregnancy induces the overexpression of GDF-3 and inflammasome-related markers, which may contribute to congenital disorders and harmful pregnancy outcomes. © 2022 by the authors. Licensee MDPI, Basel, Switzerland. | pt_BR |
dc.language.iso | en | pt_BR |
dc.relation.ispartof | Volume 14, Edição 5, Número 1004 | pt_BR |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Brazil | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/br/ | * |
dc.subject | Inflammasome | pt_BR |
dc.subject | Pregnancy | pt_BR |
dc.title | Increased Serum Levels of Growth-Differentiation Factor 3 (GDF3) and Inflammasome-Related Markers in Pregnant Women during Acute Zika Virus Infection | pt_BR |
dc.type | Artigo | pt_BR |
dc.identifier.doi | 10.3390/v14051004 | - |
dc.publisher.journal | Viruses | pt_BR |
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