Synthesis and Antimalarial Activity of Dihydroperoxides and Tetraoxanes Conjugated with Bis(benzyl)acetone Derivatives

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dc.contributor.authorFranco, Lucas Lopardi
dc.contributor.authorAlmeida, Mauro Vieira D. de
dc.contributor.authorSilva, Luiz Francisco Rocha e
dc.contributor.authorVieira, Pedro Paulo Ribeiro
dc.contributor.authorPohlit, Adrian Martin
dc.contributor.authorValle, Marcelo Siqueira
dc.date.accessioned2020-06-15T21:51:14Z
dc.date.available2020-06-15T21:51:14Z
dc.date.issued2012
dc.description.abstractDihydroperoxides and tetraoxanes derived from symmetrically substituted bis(arylmethyl)acetones were synthesized in modest to good yields using several methods. Three of these compounds exhibit an important in vitro antimalarial activity (1.0μm≤IC 50≤5.0μm) against blood forms of the human malaria parasite Plasmodium falciparum. © 2012 John Wiley & Sons A/S.en
dc.identifier.doi10.1111/j.1747-0285.2012.01345.x
dc.identifier.urihttps://repositorio.inpa.gov.br/handle/1/18053
dc.language.isoenpt_BR
dc.publisher.journalChemical Biology and Drug Designpt_BR
dc.relation.ispartofVolume 79, Número 5, Pags. 790-797pt_BR
dc.rightsRestrito*
dc.subject1,1' Peroxybis(4 Tert Butyl(hydroperoxy)cyclohexaneen
dc.subject1,5 Bis(3,4,5 Trimethoxyphenyl)pentan 3 Oneen
dc.subject1,5 Bis(4 Methoxyphenyl)pentan 3 Oneen
dc.subject1,5 Bis(phenyl)penta 1,4 Dien 3 Oneen
dc.subject1,5 Bis(phenyl)pentan 3 Oneen
dc.subject3,3 Dihydroperoxy 1,5 (bisphenyl)pentaneen
dc.subject3,3 Dihydroperoxy 1,5 Bis(4' Methoxyphenyl)pentaneen
dc.subject3,3 Diphenethyl 1,2,4,5 Tetraoxaspiro[5.5]undecaneen
dc.subject3,3,6,6 Tetraphenethyl 1,2,4,5 Tetraoxaneen
dc.subject4 Tert Butyl 1,1 Dihydroperoxycyclohexaneen
dc.subjectTetrabenzeneen
dc.subjectAcetoneen
dc.subjectAntimalarial Agenten
dc.subjectBis(arylmethyl)acetoneen
dc.subjectDihydroperoxideen
dc.subjectHydroperoxide Derivativeen
dc.subjectTetraoxane Derivativeen
dc.subjectUnclassified Drugen
dc.subjectAntimalarial Activityen
dc.subjectControlled Studyen
dc.subjectDrug Synthesisen
dc.subjectHumanen
dc.subjectIn Vitro Studyen
dc.subjectNonhumanen
dc.subjectPlasmodium Falciparumen
dc.subjectPriority Journalen
dc.subjectAcetoneen
dc.subjectAntimalarialsen
dc.subjectHumansen
dc.subjectInhibitory Concentration 50en
dc.subjectMalaria, Falciparumen
dc.subjectPeroxidesen
dc.subjectPlasmodium Falciparumen
dc.subjectStructure-activity Relationshipen
dc.subjectTetraoxanesen
dc.subjectPlasmodium Falciparumen
dc.titleSynthesis and Antimalarial Activity of Dihydroperoxides and Tetraoxanes Conjugated with Bis(benzyl)acetone Derivativesen
dc.typeArtigopt_BR

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