Please use this identifier to cite or link to this item:
https://repositorio.inpa.gov.br/handle/1/14726
Title: | Interaction between smoking and HLA-DRB1*04 gene is associated with a high cardiovascular risk in Brazilian Amazon patients with rheumatoid arthritis |
Authors: | Boechat, Narjara de Oliveira Ogusku, Maurício Morishi Boechat, Antonio Luiz Sadahiro, Aya |
Keywords: | Epitope Hla Drb1 Antigen Hla Drb5 Antigen Adult Allele Cardiovascular Risk Case Control Study Controlled Study Disease Activity Female Gene Genetic Association Genetic Risk Genetic Susceptibility Genotype-environment Interaction High Risk Population Hla Drb1 Gene Hla Drb5 Gene Human Major Clinical Study Male Arthritis, Rheumatoid Risk Assessment Smoking Habit Trend Study Adult Arthritis, Rheumatoid Cardiovascular Diseases Female Genotype Hla-drb1 Chains Humans Logistic Models Male Middle Aged Risk Smoking |
Issue Date: | 2012 |
metadata.dc.publisher.journal: | PLoS ONE |
metadata.dc.relation.ispartof: | Volume 7, Número 8 |
Abstract: | Background: Rheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the joints that affects approximately 1% of the population worldwide. The HLA-DRB1 gene locus plays a major role in genetic susceptibility to RA, a condition that has been associated with a high cardiovascular morbidity and mortality in many studies. Methodology/Principal Findings: The aim of this work was to investigate which types of HLA class II genes are associated with RA in patients from the Brazilian Amazon and their influence on high cardiovascular risk status in this population. For this purpose, a case-control study was carried out with a total of 350 non-Indian individuals made up of a cohort of 132 consecutive RA sufferers and 218 healthy controls. A χ2 test showed that HLADRB1*04 (p<0.0016; OR = 1.89; 95% CI = 1.29-2.79) and HLADRB1*10 (p = 0.0377; OR = 3.81; 95% CI = 1.16-12.50) are the major HLA genes associated with susceptibility to RA. A logistic regression model also showed that the interaction between HLADRB1*04 (p = 0.027; OR = 6.02; 95% CI = 1.21-29.7), age (p = 0.0001; OR = 1.26; 95% CI = 1.13-1.39) and smoking (p = 0.0001; OR = 23.6; 95% CI = 4.25-32.1) is associated with a probability of a high cardiovascular risk status at an early age. Conclusions/Significance: The results of this study show for the first time that HLA class II type is associated with RA in Brazilian Amazon populations and that a specific interaction between the HLA-DRB1*04 gene and smoking is associated with a high cardiovascular risk status, as initially reported in the European population. This study therefore contributes to an understanding of gene-environment interactions in RA patients. © 2012 Boechat et al. |
metadata.dc.identifier.doi: | 10.1371/journal.pone.0041588 |
Appears in Collections: | Artigos |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
artigo-inpa.pdf | 309,85 kB | Adobe PDF | ![]() View/Open |
This item is licensed under a Creative Commons License