Use este identificador para citar ou linkar para este item:
https://repositorio.inpa.gov.br/handle/1/15170
Título: | Biological and molecular properties of yellow venom of the Amazonian coral snake Micrurus surinamensis |
Autor: | Oliveira, Fabiana da Rocha Noronha, Maria das Dores Nogueira Lozano, Jorge Luis López |
Palavras-chave: | Hyaluronidase Phospholipase A2 Snake Venom Snake Venom Antiserum Phospholipase A2 Animals Experiment Animals Model Anticoagulation Biological Activity Bleeding Enzyme Activity Hypersensitivity Ld 50 Micrurus Surinamensis Mouse Neurotoxicity Nonhuman Electrophoresis, Polyacrylamide Gel Protein Degradation Snake Western Blotting Zymography Animals Bagg Albino Mouse Chemistry Cross Reaction Elapidae Electrophoresis Enzymology Genetics Metabolism Animal Cross Reactions Elapid Venoms Elapidae Electrophoresis Lethal Dose 50 Mice Mice, Inbred Balb C Phospholipases A2 |
Data do documento: | 2017 |
Revista: | Revista da Sociedade Brasileira de Medicina Tropical |
É parte de: | Volume 50, Número 3, Pags. 365-373 |
Abstract: | Introduction: The coral snake Micrurus surinamensis, which is widely distributed throughout Amazonia, has a neurotoxic venom. It is important to characterize the biological and molecular properties of this venom in order to develop effective antitoxins. Methods: Toxins from the venom of M. surinamensis were analyzed by two-dimensional polyacrylamide gel electrophoresis and their neurotoxic effects in vivo were evaluated. Results and Conclusions: Most proteins in the venom had masses < 14kDa, low phospholipase A2 activity, and no proteolytic activity. The toxins inhibited the coagulation cascade. The venom had neurotoxic effects in mice, with a median lethal dose upon intravenous administration of 700 µg/kg. Immunogenic studies revealed abundant cross-reactivity of antielapidic serum with 14kDa toxins and limited cross-reactivity with toxins < 10kDa. These results indicate that antielapidic serum against M. surinamensis venom has weak potency (0.35mg/ml) in mice. © 2017, Sociedade Brasileira de Medicina Tropical. All rights reserved. |
DOI: | 10.1590/0037-8682-0408-2016 |
Aparece nas coleções: | Artigos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
---|---|---|---|---|
artigo-inpa.pdf | 3,34 MB | Adobe PDF | Visualizar/Abrir |
Este item está licenciada sob uma Licença Creative Commons