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Title: Analgesic and anti-inflammatory effect of the aqueous extract of "trevo-roxo" (Scutellaria agrestis A. St.-Hil. Ex Benth. - Lamiaceae) leaves in rodents
Other Titles: Efeito analgésico e anti-inflamatório do extrato aquoso das folhas de trevo-roxo (Scutellaria agrestis A. St.-Hil. Ex Benth. - Lamiaceae) em roedores
Authors: Oliveira, A. B.
Barbosa, Gleyce dos Santos
Verdam, Maria Christina dos Santos
Ohana, Débora Teixeira
Mendonça, Maria Silvia de
Alves Meira, Renata Maria Strozi
Keywords: Alkaloid
Cyanogenic Heteroside
Phenol Derivative
Plant Extract
Plant Medicinal Product
Scutellaria Agrestis A Extarct
Unclassified Drug
Analgesic Activity
Animals Experiment
Animals Model
Antiedematogenic Activity
Antiinflammatory Activity
Biological Activity
Controlled Study
External Otitis
Paw Edema
Toxicity Testing
Issue Date: 2014
metadata.dc.publisher.journal: Revista Brasileira de Plantas Medicinais
metadata.dc.relation.ispartof: Volume 16, Número 2, Pags. 174-181
Abstract: The Scutellaria agrestis is used by Amazonas riverine communities, especially for otitis externa topical treatment, by using the crude extract obtained by maceration. This study aimed to investigate the preliminary phytochemical profile, the safety/toxicity and the analgesic, anti-inflammatory and antiedematogenic activities of the aqueous extract of the S. agrestis leaves. Eighty individuals were collected at the Nilton Lins University medicinal garden, Manaus, Brazil. The phytochemical profile was obtained through a plant drug survey for cyanogenic heterosides, terpenes, alkaloids and phenolic compounds. The extract safety was evaluated by acute toxicity test. Analgesic and anti-inflammatory activities were accessed using formalin test in mice and the antiedematogenic activity, using paw edema test in mice. We detected phenolic (hydrolysable tannins, coumarins and several classes of flavonoids) and terpenoid (free steroids, saponins) metabolites. We could not establish LD50because no animals died during the acute toxicity test, probably because of the absence of cyanogenic glycosides on the composition of the extract. However, we found that the extract is slightly toxic as animal spasms were observed in the first hour of the test. The extract showed significant analgesic and anti-inflammatory activity on the formalin test (30, 100 and 300 mg/kg p.o.), and the highest dose result was equivalent to the standard drug (Fentanyl). However, no significant antiedematogenic effect was observed during the paw edema test. The results obtained in this study provide preliminary scientific basis about the safety and analgesic/anti-inflammatory actions of the aqueous extract of S. agrestis, which indicates that this species is a promising option for further in vitro and in vivo pharmacological studies.
metadata.dc.identifier.doi: 10.1590/S1516-05722014000200002
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