Use este identificador para citar ou linkar para este item:
https://repositorio.inpa.gov.br/handle/1/16153
Registro completo de metadados
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Benatti, B. B. | - |
dc.contributor.author | Campos-Júnior, Jozafá C. | - |
dc.contributor.author | Silva-Filho, Vilmar J. | - |
dc.contributor.author | Alves, Polyanna Miranda | - |
dc.contributor.author | Rodrigues, Isabela R. | - |
dc.contributor.author | Uber-Bucek, Elizabeth | - |
dc.contributor.author | Manfredo Vieira, Silvio | - |
dc.contributor.author | Napimoga, Marcelo Henrique | - |
dc.date.accessioned | 2020-05-25T19:10:48Z | - |
dc.date.available | 2020-05-25T19:10:48Z | - |
dc.date.issued | 2012 | - |
dc.identifier.uri | https://repositorio.inpa.gov.br/handle/1/16153 | - |
dc.description.abstract | Objectives: The Mikania laevigata extract (MLE) (popularly known in Brazil as "guaco") possesses anti-inflammatory properties. In the present study we tested the effects of MLE in a periodontitis experimental model in rats. We also investigated possible mechanisms underlying such effects. Material and Methods: Periodontal disease was induced by a ligature placed around the mandibular first molars of each animal. Male Wistar rats were divided into 4 groups: non-ligated animals treated with vehicle; non-ligated animals treated with MLE (10 mg/kg, daily); ligature-induced animals treated with vehicle and ligature-induced animals treated with MLE (10 mg/kg, daily). Thirty days after the induction of periodontal disease, the animals were euthanized and mandibles and gingival tissues removed for further analysis. Results: Morphometric analysis of alveolar bone loss demonstrated that MLE-treated animals presented a decreased alveolar bone loss and a lower expression of the activator of nuclear factor-κB ligand (RANKL) measured by immunohistochemistry. Moreover, gingival tissues from the MLE-treated group showed decreased neutrophil migration myeloperoxidase (MPO) assay. Conclusions: These results indicate that MLE may be useful to control bone resorption during progression of experimental periodontitis in rats. | en |
dc.language.iso | en | pt_BR |
dc.relation.ispartof | Volume 20, Número 3, Pags. 340-346 | pt_BR |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Brazil | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/br/ | * |
dc.title | Effects of a Mikania laevigata extract on bone resorption and RANKL expression during experimental periodontitis in rats | en |
dc.type | Artigo | pt_BR |
dc.identifier.doi | 10.1590/S1678-77572012000300008 | - |
dc.publisher.journal | Journal of Applied Oral Science | pt_BR |
Aparece nas coleções: | Artigos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
---|---|---|---|---|
artigo-inpa.pdf | 756,18 kB | Adobe PDF | Visualizar/Abrir |
Este item está licenciada sob uma Licença Creative Commons