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Title: Cross-reactivity between Potamotrygon motoro antivenoms and dorsal and stinger extracts of others stingrays (Chondrichthyes: Potamotrygonidae) from the Amazon basin
Authors: Lameiras, Juliana Luiza Varjão
Moura, Valéria Mourão de
Dias, Lucas Castanhola
Santos, Ilia Gilmara Carvalho dos
Costa, Oscar Tadeu Ferreira da
Santos, Maria Cristina dos
Keywords: Fish Venom
Tissue Extract
Antibody Production
Antigen Antibody Reaction
Cartilaginous Fish
Cross Reaction
Dorsal Region
Enzyme-linked Immunosorbent Assay
Paratrygon Aiereba
Plesiotrygon Iwamae
Potamotrygon Motoro
Potamotrygon Orbignyi
Potamotrygon Schroederi
Western Blotting
Issue Date: 2019
metadata.dc.publisher.journal: Toxin Reviews
metadata.dc.relation.ispartof: Volume 38, Número 1, Pags. 61-70
Abstract: In this study, two mouse hyperimmune sera were produced, one using extract from the stinger of the stingray Potamotrygon motoro and the other using extract from the dorsal region of the same species and their cross-reactivity with extracts from the following species of stingrays from the Amazon basin was investigated using Western blot and dot ELISA: Paratrygon aiereba, Plesiotrygon iwamae, Potamotrygon orbignyi and Potamotrygon schroederi. The results show that the dorsal extract was as immunogenic as the stinger extract and induced high levels of antibodies, which reacted with homologous and heterologous antigens, indicating that both types of extract may be suitable for use in the production of antivenom to treat victims of envenomation by stingrays. © 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group.
metadata.dc.identifier.doi: 10.1080/15569543.2017.1394324
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