Use este identificador para citar ou linkar para este item: https://repositorio.inpa.gov.br/handle/1/17332
Título: Structure and antinociceptive effects of β-d-glucans from Cookeina tricholoma
Autor: Moreno, Roberta Barbara
Ruthes, Andrea Caroline
Baggio, C. H.
Vilaplana, Francisco
Komura, Dirce Leimi
Iacomini, Marcello
Palavras-chave: Chains
Fungi
Antinociceptive Effect
Ascomycete
Brazilian Amazon
Cookeina Tricholoma
Extractability
Glucans
Substitution Patterns
Wild Edible Mushrooms
Polysaccharides
Analgesic Agent
Fungal Polysaccharide
Glucan
Animals
Ascomycetes
Chemistry
Drug Effects
Female
Mouse
Nociception
Analgesics
Animal
Ascomycota
Female
Fungal Polysaccharides
Glucans
Mice
Nociception
Data do documento: 2016
Revista: Carbohydrate Polymers
É parte de: Volume 141, Pags. 220-228
Abstract: Structurally different water-insoluble (1 → 3),(1 → 6) β-d-glucans were isolated from aqueous and alkaline extracts of the mushroom-forming ascomycete Cookeina tricholoma, a wild edible mushroom found in Brazilian Amazon forest. The structures showed different substitution patterns, which may influence their extractability and consequently their conformation in solution, and different MW (4.3 × 105 Da, 3.7 × 105 Da and 8.2 × 105 Da, for ICW-Ct, IHW-Ct and IK2-Ct, respectively). The main-chains are composed of (1 → 3)-linked β-d-Glcp units O-6 substituted by side chains with different lengths of (1 → 6)-linked β-d-Glcp units (ICW-Ct and IHW-Ct) or by a combination of (1 → 6)-linked β-d-Glcp units and single units of β-d-Glcp (IK2-Ct). β-d-glucans with similar MW and showing only (1 → 6)-linked β-d-Glcp units as side chains (ICW-Ct and IHW-Ct) showed significant inhibition of neurogenic pain, 69 ± 11 and 57 ± 11% at the dose of 10 mg kg-1, respectively, in the model of nociception induced by intraplantar injection of formalin. © 2016 Published by Elsevier Ltd.
DOI: 10.1016/j.carbpol.2016.01.001
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