Use este identificador para citar ou linkar para este item: https://repositorio.inpa.gov.br/handle/1/17372
Título: GNBP domain of Anopheles darlingi: are polymorphic inversions and gene variation related to adaptive evolution?
Autor: Bridi, Letícia C.
Rafael, Míriam Silva
Palavras-chave: Animals
Anopheles
Chromosomal Mapping
Chromosome Inversion
Disease Carrier
Evolution
Gene
Genetics
Immunology
Phylogeny
Polytene Chromosome
South America
Animal
Anopheles
Biological Evolution
Chromosome Inversion
Genes, Insect
Insect Vectors
Phylogeny
Physical Chromosome Mapping
Polytene Chromosomes
South America
Data do documento: 2016
Revista: Genetica
Encontra-se em: Volume 144, Número 1, Pags. 99-106
Abstract: Anopheles darlingi is the main malaria vector in humans in South America. In the Amazon basin, it lives along the banks of rivers and lakes, which responds to the annual hydrological cycle (dry season and rainy season). In these breeding sites, the larvae of this mosquito feed on decomposing organic and microorganisms, which can be pathogenic and trigger the activation of innate immune system pathways, such as proteins Gram-negative binding protein (GNBP). Such environmental changes affect the occurrence of polymorphic inversions especially at the heterozygote frequency, which confer adaptative advantage compared to homozygous inversions. We mapped the GNBP probe to the An. darlingi 2Rd inversion by fluorescent in situ hybridization (FISH), which was a good indicator of the GNBP immune response related to the chromosomal polymorphic inversions and adaptative evolution. To better understand the evolutionary relations and time of divergence of the GNBP of An. darlingi, we compared it with nine other mosquito GNBPs. The results of the phylogenetic analysis of the GNBP sequence between the species of mosquitoes demonstrated three clades. Clade I and II included the GNBPB5 sequence, and clade III the sequence of GNBPB1. Most of these sequences of GNBP analyzed were homologous with that of subfamily B, including that of An. gambiae (87 %), therefore suggesting that GNBP of An. darling belongs to subfamily B. This work helps us understand the role of inversion polymorphism in evolution of An. darlingi. © 2016, Springer International Publishing Switzerland.
DOI: 10.1007/s10709-016-9881-6
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