Please use this identifier to cite or link to this item: https://repositorio.inpa.gov.br/handle/1/17474
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dc.contributor.authorDelunardo, Frederico Augusto Cariello-
dc.contributor.authorCarvalho, Luciano Rodrigues de-
dc.contributor.authorSilva, Bruno Ferreira da-
dc.contributor.authorGalão, Michel-
dc.contributor.authorVal, Adalberto Luis-
dc.contributor.authorChippari-Gomes, Adriana Regina-
dc.date.accessioned2020-06-15T21:43:20Z-
dc.date.available2020-06-15T21:43:20Z-
dc.date.issued2015-
dc.identifier.urihttps://repositorio.inpa.gov.br/handle/1/17474-
dc.description.abstractThis study explored the suitability of the seahorse Hippocampus reidi (Ginsburg, 1933) for assessing biomarkers of genotoxic effects and its use as a sentinel organism to detect the effects of acute exposure to petroleum hydrocarbons. Fish were exposed to three concentrations of crude oil (10, 20 and 30. g/kg) for 96. h, and the activity of phase II biotransformation enzyme glutathione S-transferase (GST) was measured. In addition, we performed genotoxicity assays, such as comet assay, micronucleus (MN) test and nuclear abnormalities (NA) induction, on the erythrocytes of the fish species. Our results revealed that the inhibition of hepatic GST activity in H. reidi was dependent on increasing crude oil concentrations. In contrast, an increase in the damage index (DI) and MN frequency were observed with increased crude oil concentrations. These results indicate that the alkaline comet assay and micronucleus test were suitable and useful in the evaluation of the genotoxicity of crude oil, which could improve determinations of the impact of oil spills on fish populations. In addition, H. reidi is a promising "sentinel organism" to detect the genotoxic impact of petroleum hydrocarbons. © 2015.en
dc.language.isoenpt_BR
dc.relation.ispartofVolume 117, Pags. 28-33pt_BR
dc.rightsRestrito*
dc.subjectGlutathione Transferaseen
dc.subjectPetroleumen
dc.subjectGlutathione Transferaseen
dc.subjectLeukotriene-c4 Synthaseen
dc.subjectPetroleumen
dc.subjectWater Pollutanten
dc.subjectBioindicatoren
dc.subjectBiomarkeren
dc.subjectBiotransformationen
dc.subjectCrude Oilen
dc.subjectFishen
dc.subjectGenotoxicityen
dc.subjectInhibitionen
dc.subjectOil Spillsen
dc.subjectPetroleum Hydrocarbonen
dc.subjectPollution Exposureen
dc.subjectAdulten
dc.subjectAnimals Cellen
dc.subjectBiotransformationen
dc.subjectComet Assayen
dc.subjectConcentration (parameters)en
dc.subjectControlled Studyen
dc.subjectEcotoxicityen
dc.subjectEnvironmental Exposureen
dc.subjectEnzyme Activityen
dc.subjectEnzyme Inhibitionen
dc.subjectFishen
dc.subjectGenotoxicityen
dc.subjectHippocampus Reidien
dc.subjectIndicator Organismen
dc.subjectMicronucleus Testen
dc.subjectNonhumanen
dc.subjectAnalysisen
dc.subjectAnimalsen
dc.subjectDna Damageen
dc.subjectDrug Effectsen
dc.subjectErythrocyteen
dc.subjectEvaluation Studyen
dc.subjectMetabolismen
dc.subjectOil Spillsen
dc.subjectSmegmamorphaen
dc.subjectToxicityen
dc.subjectWater Pollutanten
dc.subjectHippocampus Reidien
dc.subjectAnimalen
dc.subjectComet Assayen
dc.subjectDna Damageen
dc.subjectErythrocytesen
dc.subjectGlutathione Transferaseen
dc.subjectMicronucleus Testsen
dc.subjectPetroleumen
dc.subjectPetroleum Pollutionen
dc.subjectSmegmamorphaen
dc.subjectWater Pollutants, Chemicalen
dc.titleSeahorse (Hippocampus reidi) as a bioindicator of crude oil exposureen
dc.typeArtigopt_BR
dc.identifier.doi10.1016/j.ecoenv.2015.03.016-
dc.publisher.journalEcotoxicology and Environmental Safetypt_BR
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