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Campo DC | Valor | Idioma |
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dc.contributor.author | Silva, George Allan Villarouco da | - |
dc.contributor.author | Ramasawmy, Rajendranath | - |
dc.contributor.author | Boechat, Antonio Luiz | - |
dc.contributor.author | Morais, A. C. | - |
dc.contributor.author | Carvalho, B. K.S. | - |
dc.contributor.author | Sousa, K. B A | - |
dc.contributor.author | Souza, V. C. | - |
dc.contributor.author | Cunha, Maria Coelho Graça Souza | - |
dc.contributor.author | Barletta-Naveca, Raphaela Honorato | - |
dc.contributor.author | Santos, M. P. | - |
dc.contributor.author | Naveca, Felipe Gomes | - |
dc.date.accessioned | 2020-06-15T21:48:05Z | - |
dc.date.available | 2020-06-15T21:48:05Z | - |
dc.date.issued | 2015 | - |
dc.identifier.uri | https://repositorio.inpa.gov.br/handle/1/17493 | - |
dc.description.abstract | Polymorphisms present in the TNF promoter region has shown to influence the gene transcription. Leprosy displays different clinical manifestations according to the immune responses of the individual infected with Mycobacterium leprae. In this study, we evaluated the single nucleotide polymorphisms (SNPs) -238 G/A (rs361525), -308 G/A (rs1800629), -857 C/T (rs1799724), -863 A/C (rs1800630) and -1031 T/C (rs1799964) in the promoter region of the TNF to see whether these SNPs influence host-susceptibility to leprosy and the different clinical manifestation. Nucleotide sequencing was performed with DNA samples from 108 leprosy patients and 253 control subjects. An association between -1031 C/C genotype and protection from leprosy was observed when leprosy patients were compared to controls (OR 0.11; 95% CI. =. 0.01-0.82; p=. 0.012). The -857 C/T genotype may be associated with susceptibility to leprosy (OR. =. 1.81; 95% CI. =. 1.09-3.00; p=. 0.028). Similar genotype and allele frequencies for the SNPs -308 G/A and -238 G/A were observed between leprosy patients and control subjects. Altogether, TNF polymorphisms in the promoter region may be predictive of leprosy outcome. © 2015 American Society for Histocompatibility and Immunogenetics. | en |
dc.language.iso | en | pt_BR |
dc.relation.ispartof | Volume 76, Número 2-3, Pags. 137-141 | pt_BR |
dc.rights | Restrito | * |
dc.subject | Dna | en |
dc.subject | Nucleotide | en |
dc.subject | Tumor Necrosis Factor | en |
dc.subject | Biological Marker | en |
dc.subject | Tumor Necrosis Factor-alpha | en |
dc.subject | Amazona | en |
dc.subject | Controlled Study | en |
dc.subject | Female | en |
dc.subject | Gene Frequency | en |
dc.subject | Genetic Association | en |
dc.subject | Genotype | en |
dc.subject | Host Susceptibility | en |
dc.subject | Human | en |
dc.subject | Leprosy | en |
dc.subject | Major Clinical Study | en |
dc.subject | Male | en |
dc.subject | Outcome Assessment | en |
dc.subject | Priority Journal | en |
dc.subject | Promoter Region | en |
dc.subject | Polymorphism, Single Nucleotide | en |
dc.subject | Disease Course | en |
dc.subject | Genetic Association | en |
dc.subject | Genetic Predisposition | en |
dc.subject | Genetics | en |
dc.subject | Genotype | en |
dc.subject | Immunology | en |
dc.subject | Leprosy | en |
dc.subject | Metabolism | en |
dc.subject | Mycobacterium Leprae | en |
dc.subject | Nucleotide Sequence | en |
dc.subject | Predictive Value | en |
dc.subject | Promoter Region | en |
dc.subject | Biomarkers | en |
dc.subject | Disease Progression | en |
dc.subject | Dna Mutational Analysis | en |
dc.subject | Gene Frequency | en |
dc.subject | Genetic Association Studies | en |
dc.subject | Genetic Predisposition To Disease | en |
dc.subject | Genotype | en |
dc.subject | Humans | en |
dc.subject | Leprosy | en |
dc.subject | Mycobacterium Leprae | en |
dc.subject | Polymorphism, Single Nucleotide | en |
dc.subject | Predictive Value Of Tests | en |
dc.subject | Promoter Regions, Genetic | en |
dc.subject | Tumor Necrosis Factor-alpha | en |
dc.title | Association of TNF -1031 C/C as a potential protection marker for leprosy development in Amazonas state patients, Brazil | en |
dc.type | Artigo | pt_BR |
dc.identifier.doi | 10.1016/j.humimm.2015.01.011 | - |
dc.publisher.journal | Human Immunology | pt_BR |
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