Use este identificador para citar ou linkar para este item: https://repositorio.inpa.gov.br/handle/1/17843
Título: Isolation and identification of α-glucosidase, α-amylase and lipase inhibitors from Hortia longifolia
Autor: Queiroz, Darlene P.K.
Ferreira, Antonio Gilberto
Lima, Arleilson Sousa
Lima, Emerson Silva
Lima, Maria da Paz
Palavras-chave: Acarbose
Alpha Glucosidase
Amide
Amylase
Cinnamic Acid Derivative
Coumarin
Ferulic Acid
Hortia Longifolia Extract
Limonin
Plant Extract
Scopoletin
Skimmianine
Triacylglycerol Lipase
Unclassified Drug
Carbon Nuclear Magnetic Resonance
Column Chromatography
Controlled Study
Correlation Analysis
Drug Identification
Drug Isolation
Enzymatic Assay
Extraction
Fractionation
Hortia Longifolia
Ic 50
Nonhuman
Plant
Proton Nuclear Magnetic Resonance
Chromatography, Thin Layer
Data do documento: 2013
Revista: International Journal of Pharmacy and Pharmaceutical Sciences
É parte de: Volume 5, Número 3, Pags. 336-339
Abstract: Phytochemical investigation from branches of Hortia longifolia (Rutaceae) yielded the amide N-[2-(4-prenyloxyphenyl)ethyl]tigliamide (1), (E)-methyl-O-prenyl ferulate (2), limonin (3), cinnamic acid derivatives [(E)-methyl-5'-hydroxy-O-prenyl cinnamate 4 and integrifoliodiol 7], scopoletin (5) and skimmianine (6). The compound 4 showed moderate α-amylase inhibitory activity, the coumarin 5 presented strong activity on α-glucosidase (IC50 of 0.89 μg/mL). The compounds 1, 2, 4 and 5 exhibited significant inhibitory activity on lipase with IC50 at 6.91, 8.14, 3.86 and 5.07 μg/mL, respectively. The results demonstrate potential use for these compounds in development of drugs of natural origin in the prevention or treatment of metabolic syndrome.
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