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https://repositorio.inpa.gov.br/handle/1/17872| Title: | Association between the PTPN22 1858C/T gene polymorphism and tuberculosis resistance |
| Authors: | Boechat, Antonio Luiz Ogusku, Maurício Morishi Sadahiro, Aya Santos, Maria Cristina dos |
| Keywords: | Genomic Dna Case Control Study Controlled Study Disease Predisposition Dna Polymorphism Ethnic Difference Gene Gene Frequency Gene Function Gene Linkage Disequilibrium Genetic Variability Genotype Geographic Distribution Human Lung Tuberculosis Major Clinical Study Mycobacterium Tuberculosis Population Research Priority Journal Ptpn22 Gene Polymorphism, Single Nucleotide Alleles Case-control Studies Disease Resistance Genetic Association Studies Humans Mutation Odds Ratio Polymorphism, Single Nucleotide Protein Tyrosine Phosphatase, Non-receptor Type 22 Tuberculosis, Pulmonary |
| Issue Date: | 2013 |
| metadata.dc.publisher.journal: | Infection, Genetics and Evolution |
| metadata.dc.relation.ispartof: | Volume 16, Pags. 310-313 |
| Abstract: | Previous studies identified the functional polymorphism 1858C/T in the gene PTPN22 in association with several autoimmune diseases and with resistance to tuberculosis (TB). This study is the first to investigate the association between pulmonary TB and the PTPN22 1858C/T polymorphism in the Brazilian Amazon. We conducted a case-control study involving a group of 413 individuals, comprised of 208. TB carriers and 205 controls. No significant association between the PTPN22 1858T allele frequency in controls (2.4%) and TB carriers (2.7%, p= 0.982, odds ratio (OR). = 0.89, 95% confidence interval. = 0.37-2.13) was identified in the Brazilian Amazon population. An additional evaluation by meta-analysis, however, suggested a protective role of the T allele in relation to TB (pooled OR. = 0.44, p= 0.011). These results suggest that the PTPN22 1858T allele serves as a protective genetic factor for TB in those individuals who carry this minor allele. © 2013 Elsevier B.V. |
| metadata.dc.identifier.doi: | 10.1016/j.meegid.2013.02.019 |
| Appears in Collections: | Artigos |
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