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Title: Association between the PTPN22 1858C/T gene polymorphism and tuberculosis resistance
Authors: Boechat, Antonio Luiz
Ogusku, Maurício Morishi
Sadahiro, Aya
Santos, Maria Cristina dos
Keywords: Genomic Dna
Case Control Study
Controlled Study
Disease Predisposition
Dna Polymorphism
Ethnic Difference
Gene Frequency
Gene Function
Gene Linkage Disequilibrium
Genetic Variability
Geographic Distribution
Lung Tuberculosis
Major Clinical Study
Mycobacterium Tuberculosis
Population Research
Priority Journal
Ptpn22 Gene
Polymorphism, Single Nucleotide
Case-control Studies
Disease Resistance
Genetic Association Studies
Odds Ratio
Polymorphism, Single Nucleotide
Protein Tyrosine Phosphatase, Non-receptor Type 22
Tuberculosis, Pulmonary
Issue Date: 2013
metadata.dc.publisher.journal: Infection, Genetics and Evolution
metadata.dc.relation.ispartof: Volume 16, Pags. 310-313
Abstract: Previous studies identified the functional polymorphism 1858C/T in the gene PTPN22 in association with several autoimmune diseases and with resistance to tuberculosis (TB). This study is the first to investigate the association between pulmonary TB and the PTPN22 1858C/T polymorphism in the Brazilian Amazon. We conducted a case-control study involving a group of 413 individuals, comprised of 208. TB carriers and 205 controls. No significant association between the PTPN22 1858T allele frequency in controls (2.4%) and TB carriers (2.7%, p= 0.982, odds ratio (OR). = 0.89, 95% confidence interval. = 0.37-2.13) was identified in the Brazilian Amazon population. An additional evaluation by meta-analysis, however, suggested a protective role of the T allele in relation to TB (pooled OR. = 0.44, p= 0.011). These results suggest that the PTPN22 1858T allele serves as a protective genetic factor for TB in those individuals who carry this minor allele. © 2013 Elsevier B.V.
metadata.dc.identifier.doi: 10.1016/j.meegid.2013.02.019
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