Use este identificador para citar ou linkar para este item: https://repositorio.inpa.gov.br/handle/1/18169
Título: In vivo and in vitro antimalarial activity of 4-nerolidylcatechol
Autor: Silva, Luiz Francisco Rocha e
Pinto, Ana Cristina da Silva
Pohlit, Adrian Martin
Quignard, Etienne Louis Jacques
Vieira, Pedro Paulo Ribeiro
Tadei, Wanderli Pedro
Chaves, Francisco Célio Maia
Samonek, Jean Francisco
Lima, Carlos Alberto Jatoba
Costa, Mônica Regina Farias
Alecrim, Maria das Graças Costa
Andrade Neto, Valter Ferreira de
Palavras-chave: 4 Nerolidylcatechol
Antimalarial Agent
Catechol Derivative
Chloroquine
Unclassified Drug
Animals Cell
Animals Experiment
Animals Model
Antimalarial Activity
Blood Sampling
Concentration (parameters)
Controlled Study
Drug Determination
Drug Dose Comparison
Drug Inhibition
Drug Metabolism
Drug Structure
Female
Growth Inhibition
Human
Human Cell
In Vitro Study
In Vivo Study
Malaria
Microbial Growth
Mouse
Nonhuman
Piper Peltatum
Piperaceae
Plasmodium Berghei
Plasmodium Falciparum
Treatment Response
Animal
Antimalarials
Catechols
Disease Models, Animals
Female
Malaria
Malaria, Falciparum
Mice
Piper
Plasmodium Berghei
Plasmodium Falciparum
Murinae
Mus
Piper Peltatum
Piperaceae
Plasmodium Berghei
Plasmodium Falciparum
Data do documento: 2011
Revista: Phytotherapy Research
É parte de: Volume 25, Número 8, Pags. 1181-1188
Abstract: 4-Nerolidylcatechol (4-NC) isolated from Piper peltatum L. (Piperaceae) was evaluated for in vitro antiplasmodial activity against Plasmodium falciparum (cultures of both standard CQR (K1) and CQS (3D7) strains and two Amazonian field isolates) and for in vivo antimalarial activity using the Plasmodium berghei-murine model. 4-NC exhibits significant in vitro and moderate in vivo antiplasmodial activity. 4-NC administered orally and subcutaneously at doses of 200, 400 and 600 mg/kg/day suppressed the growth of P. berghei by up to 63% after four daily treatments (days 1-4). Also, 4-NC exhibited important in vitro antiplasmodial activity against both standard and field P. falciparum strains in which 50% inhibition of parasite growth (IC 50) was produced at concentrations of 0.05-2.11 μg/mL and depended upon the parasite strain. Interestingly, healthy (non-infected) mice that received 4-NC orally presented (denatured) blood plasma which exhibited significant in vitro activity against P. falciparum. This is evidence that mouse metabolism allows 4-NC or active metabolites to enter the blood. Further chemical and pharmacological studies are necessary to confirm the potential of 4-NC as a new antimalarial prototype. Copyright © 2011 John Wiley & Sons, Ltd.
DOI: 10.1002/ptr.3424
Aparece nas coleções:Artigos

Arquivos associados a este item:
Não existem arquivos associados a este item.


Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.