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https://repositorio.inpa.gov.br/handle/1/19509| Title: | A new antimalarial quassinoid from Simaba guianensis |
| Authors: | Cabral, Jose A. McChesney, James Dewey Milhous, Wilbur K. |
| Keywords: | Quassinoid Derivative Antimalarial Activity Drug Isolation Drug Structure Nonhuman Plasmodium Falciparum Tree Animals Antimalarials Bicyclo Compounds Chromatography, Thin Layer Glaucarubin Magnetic Resonance Spectroscopy Plant Extracts Plants, Medicinal Plasmodium Falciparum Spectrophotometry, Ultraviolet Support, Non-u.S. Gov't Plasmodium Falciparum Quassia Quassia Africana Simaba |
| Issue Date: | 1993 |
| metadata.dc.publisher.journal: | Journal of Natural Products |
| metadata.dc.relation.ispartof: | Volume 56, Número 11, Pags. 1954-1961 |
| Abstract: | Two antimalarial quassinoids, gutolactone [1] and simalikalactone D [2], have been characterized by bioactivity-directed fractionation from the bark of Simaba guianensis collected near Manaus, Brazil. Compound 2 was previously isolated from Simaba multiflora and Quassia africana and shown to be an active antimalarial in vitro. This is the first occurrence of 1. The structure of the novel quassinoid was established by spectral methods including 2D nmr spectroscopy. © 1993, American Chemical Society. All rights reserved. |
| metadata.dc.identifier.doi: | 10.1021/np50101a014 |
| Appears in Collections: | Artigos |
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