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Campo DC | Valor | Idioma |
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dc.contributor.author | Poleto, Liliane | - |
dc.contributor.author | da Rosa, Letícia Osório | - |
dc.contributor.author | Fontana, Roselei Claudete | - |
dc.contributor.author | Rodrigues, Eliseu | - |
dc.contributor.author | Poletto, Édina | - |
dc.contributor.author | Baldo, Guilherme | - |
dc.contributor.author | Paesi, Suelen Osmarina | - |
dc.contributor.author | Campos, Ceci Sales da Gama | - |
dc.contributor.author | Camassola, Marli | - |
dc.date.accessioned | 2021-04-09T18:19:19Z | - |
dc.date.available | 2021-04-09T18:19:19Z | - |
dc.date.issued | 2021 | - |
dc.identifier.uri | https://repositorio.inpa.gov.br/handle/1/37398 | - |
dc.description.abstract | The antimicrobial activity of the metabolites produced by Fusarium oxysporum PR-33 in submerged culture was evaluated against Gram-positive and Gram-negative bacteria and yeasts. Metabolites were determined by HPLC–DAD-MS/MS. An extract was obtained following the removal of mycelium by centrifugation and lyophilisation of the supernatant. The compounds in this extract demonstrated broad-spectrum antimicrobial action, with rates of inhibition between 60 and 80%, depending on the species and extract tested. The major compounds of the extracts were identified as fusarinolic acid and its isomer [56.9% flask extract (FE)] and 59.2% bioreactor extract (BE), dehydrofusaric acid (35.7% FE and 31.6% BE), and fusaric acid (6.5% FE and 1.1% BE). Fusaric acid has been shown to be responsible for antimicrobial activity. The cytotoxicity of the extracts was evaluated in culture of HEK-293 and SH-SY5Y animal cells and toxicity of these extracts was verified even in the lowest tested concentrations. Therefore, our results indicate that the compounds identified exhibit potential as antimicrobial agents. | en |
dc.subject | Antibiotics | en |
dc.subject | Biopharmaceuticals | en |
dc.subject | Antimicrobial agents | en |
dc.subject | Antimicrobial resistance | en |
dc.subject | Screening test | en |
dc.title | Production of antimicrobial metabolites against pathogenic bacteria and yeasts by Fusarium oxysporum in submerged culture processes | en |
dc.type | Artigo | pt_BR |
dc.identifier.doi | https://doi.org/10.1007/s00449-021-02538-2 | - |
dc.publisher.journal | Bioprocess and Biosystems Engineering | en |
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