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Title: Endophytic fungus Phomopsis sp. as a source of 3-nitropropionic acid with larvicidal activity against Aedes aegypti (Linnaeus 1762, Diptera: Culicidae)
Authors: Garcia, Armando da Costa
Menezes Júnior, Orivaldo Teixeira de
Mariano, Lissa Apolonia
Santiago, Letícia Corrêa
Araújo, Ângela Regina
Monfardini, Julia Dietsche
Simões, Rejane de Castro
Oliveira, André Correa de
Roque, Rosemary Aparecida
Tadei, Wanderli Pedro
Teles, Helder Lopes
Oliveira, Camila Martins de
Keywords: Biomonitored chemical
Aedes aegypti
Secondary metabolite
Issue Date: 2022
metadata.dc.publisher.journal: Revista da Sociedade Brasileira de Medicina Tropical
metadata.dc.relation.ispartof: Volume 55
Abstract: Background: Aedes aegypti is the primary vector of viruses, such as Zika, chikungunya, yellow fever, and dengue. In this context, a biomonitored chemical study was conducted to evaluate the activity of the crude extract of the endophytic fungus Phomopsis sp. against the larvae of Aedes aegypti. Methods: Crude extract, fractions, and isolated substances were evaluated in in-vitro assays against third-stage larvae of Aedes aegypti. Results: We isolated 3-nitropropionic acid with an LC50 of 15.172 ppm and LC90 of 18.178 ppm after 24 hours of larval exposure. Conclusions: The results indicated that 3-nitropropionic acid exerted larvicidal activity. © 2022, Sociedade Brasileira de Medicina Tropical. All rights reserved.
ISSN: 00378682
metadata.dc.identifier.doi: 10.1590/0037-8682-0018-2022
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