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Title: Association of TNF -1031 C/C as a potential protection marker for leprosy development in Amazonas state patients, Brazil
Authors: Silva, George Allan Villarouco da
Ramasawmy, Rajendranath
Boechat, Antonio Luiz
Morais, A. C.
Carvalho, B. K.S.
Sousa, K. B A
Souza, V. C.
Cunha, Maria Coelho Graça Souza
Barletta-Naveca, Raphaela Honorato
Santos, M. P.
Naveca, Felipe Gomes
Keywords: Dna
Tumor Necrosis Factor
Biological Marker
Tumor Necrosis Factor-alpha
Controlled Study
Gene Frequency
Genetic Association
Host Susceptibility
Major Clinical Study
Outcome Assessment
Priority Journal
Promoter Region
Polymorphism, Single Nucleotide
Disease Course
Genetic Association
Genetic Predisposition
Mycobacterium Leprae
Nucleotide Sequence
Predictive Value
Promoter Region
Disease Progression
Dna Mutational Analysis
Gene Frequency
Genetic Association Studies
Genetic Predisposition To Disease
Mycobacterium Leprae
Polymorphism, Single Nucleotide
Predictive Value Of Tests
Promoter Regions, Genetic
Tumor Necrosis Factor-alpha
Issue Date: 2015
metadata.dc.publisher.journal: Human Immunology
metadata.dc.relation.ispartof: Volume 76, Número 2-3, Pags. 137-141
Abstract: Polymorphisms present in the TNF promoter region has shown to influence the gene transcription. Leprosy displays different clinical manifestations according to the immune responses of the individual infected with Mycobacterium leprae. In this study, we evaluated the single nucleotide polymorphisms (SNPs) -238 G/A (rs361525), -308 G/A (rs1800629), -857 C/T (rs1799724), -863 A/C (rs1800630) and -1031 T/C (rs1799964) in the promoter region of the TNF to see whether these SNPs influence host-susceptibility to leprosy and the different clinical manifestation. Nucleotide sequencing was performed with DNA samples from 108 leprosy patients and 253 control subjects. An association between -1031 C/C genotype and protection from leprosy was observed when leprosy patients were compared to controls (OR 0.11; 95% CI. =. 0.01-0.82; p=. 0.012). The -857 C/T genotype may be associated with susceptibility to leprosy (OR. =. 1.81; 95% CI. =. 1.09-3.00; p=. 0.028). Similar genotype and allele frequencies for the SNPs -308 G/A and -238 G/A were observed between leprosy patients and control subjects. Altogether, TNF polymorphisms in the promoter region may be predictive of leprosy outcome. © 2015 American Society for Histocompatibility and Immunogenetics.
metadata.dc.identifier.doi: 10.1016/j.humimm.2015.01.011
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